A better understanding of how genetic variants contribute to the pathogenesis of cardiac diseases will necessitate exploration of how functions beyond splicing are impacted bit.ly/3DkHM9d

This review discusses the distribution, regulation, and mechanisms of cytoplasmic polyadenylation element-binding proteins (CPEBs), highlighting their dual roles in either promoting or repressing gene expression depending on cellular context. bit.ly/41pFqhp

Here, we discuss promising approaches employed to regulate NMD for therapeutic purposes and highlight potential challenges in future clinical development. We are optimistic of the future of developing target-specific and global modulators of NMD. bit.ly/3F86Ron

Adenosine to inosine conversion by adenosine deaminases acting on RNA (ADARs) was first identified in the late 1980s. How to interpret the consequences and alterations of RNA-editing events in whole transciptome editomes is a matter of debate. bit.ly/3F3Vqy1

Activated protein synthesis is a hallmark of cancer. Targeting eukaryotic translation initiation factor 4F (eIF4F) complex has been identified as a promising strategy for cancer treatment. bit.ly/3F4Sv8g

Here we outline the current structural and functional knowledge of the minor spliceosome, explore the mechanistic consequences of its mutations, and discuss emerging challenges in connecting molecular dysfunctions to clinical phenotypes bit.ly/4bt3aWz

I reflect on how these and other contributions (e.g., nucleocytoplasmic shuttling, telescripting) originated from curiosity-driven exploration and highly collaborative lab culture bit.ly/3Xv2hGX

Recurrent somatic mutations in the gene encoding the core splicing factor SF3B1 are drivers of multiple cancers. We discuss how specific transcripts affected by aberrant splicing in SF3B1-mutant cells contribute to the initiation and progression of cancer bit.ly/4bqmRy2

New Reporters for monitoring cellular NMD bit.ly/4j4jP5N

The affinity of [4Fe-4S]-dependent tRNA thiolases for tRNA does not depend on the presence of the cluster bit.ly/4lqVKaJ

🎉 The 30th #RNAMeeting is officially underway in San Diego! ☀️ We’re really kicking off the week with the Jr RNA Scientists, beach balls, good vibes, and exciting activities ahead! 🧬🏖️ Stay tuned for career panels, networking, and more! #RNA25 #ScienceWithStyle The RNA Society

Taira, Zhu, and Fukunaga report that Drosophila RNA-binding protein CG44249/Miso (minor splicing and oogenesis) binds U11 and U12 snRNAs and is crucial for minor splicing and oogenesis. bit.ly/3EoZsRp

N6-methyladenine (m6A) is the most prevalent internal chemical modification on mammalian mRNA. Here we reveal distinct features of conserved and unique m6A sites in mammals. bit.ly/3SN6YZZ

UPF2 dynamically interacts with RNA and remodels structured RNA. UPF3B stabilizes UPF1-UPF2‘s RNA association, while UPF2 supports UPF1’s RNA unfolding activity, corroborating mRNA degradation. bit.ly/3SD2rtj

SMDesigner automates the generation of mutations to assess predicted secondary structures and functions of conserved RNA structures based on sequence alignments. #ncRNA #RNA structure Institut national de la recherche scientifique bit.ly/3Fl7yet

Pervasive formation of double-stranded RNAs by overlapping sense/antisense transcripts in budding yeast mitosis and meiosis. bit.ly/4kbfRc1

RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops. bit.ly/3YTwlNq

Mutations in Nsun7 gene cause male infertility disrupting sperm tail structure and motility. NSUN7 is present in sperm precursor cells and downregulates its RNA interactors specific to this cell type. bit.ly/45mDDgs

What role does the sarcin-ricin loop (SRL) play in 50S subunit biogenesis? Our data suggest that one or more SRL-dependent GTPases are needed for dissociation of assembly factors during the process. #SarcinRicinLoop #Ribosome_biogenesis #RNA OSU Center for RNA Biology bit.ly/3F5QjOj

The Microsensor system reveals how the DGCR8-E518K mutation, linked to Wilms tumor, disrupts Microprocessor activity and miRNA maturation, offering new insights into pediatric kidney cancer mechanisms. bit.ly/3F5QmJZ