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Corrigendum to "A PKD1L3 splice variant in taste buds is not cleaved at the G proteincoupled receptor proteolytic site" Biochem. Biophys. Res. Commun. 512 2019 812818. bioportfol.io/R49wSQ

High Yield Monolayer Graphene Grids for Near-Atomic Resolution Cryo-Electron Microscopy biorxiv.org/content/10.110…

New instruction VIDEO online now！Raw data has been deposited to EMPIAR-10335. Please check it out! 😎Nieng Yan Yimo Han #Graphene_Grid

Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signalling. dlvr.it/Rbh3qQ

Truly fantastic work spearheaded by Aleks Antanasijevic and Charlie Bowman - elucidating sequences from cryo-EM density maps of serum-derived polyclonal antibodies bound to antigen. Incredibly cool! biorxiv.org/content/10.110…

In Science Magazine: Mark Davis' group (Stanford Immunology) reports KIR+ #CD8 #TCells = regulatory subset that ↑ in conditions like #CeliacDisease & severe #COVID19! Mouse experiments suggest this pop may reg #autoimmune responses following viral infection! bit.ly/Sci_abi9591

We're thrilled to welcome Anping Zeng, a world-renowned scientist in biotechnology, as chair professor of synthetic biology and bioengineering as well as founding director of the Center for Synthetic Biology and Integrated Bioengineering at Westlake! en.westlake.edu.cn/news_events/we…

Excited to share the news: I will start my lab HHMI | Janelia and join the 4D Cellular Physiology area. We will work on systems cell surface biology, combining method development and mechanistic investigation on neuro-immune crosstalk. lilab.science

The cilia enriched oxysterol 7β,27-DHC is required for polycystin activation biorxiv.org/cgi/content/sh… #bioRxiv

The cilia enriched oxysterol 7β,27-DHC is required for polycystin activation biorxiv.org/cgi/content/sh… #biorxiv_physio

Join us online later today as we celebrate the winners of the first Michelson Philanthropies & Science Magazine Prize for #Immunology!

Congrats to Shristi Pawnikar for publishing first-authored paper on mechanism of polycystin-1 in PNASNews! The work is in collaboration with Robin Maser lab (Brenda and Ericka) at KUMC! Mechanism of tethered agonist-mediated signaling by polycystin-1 pnas.org/doi/10.1073/pn…

The Nuclear Pore Complex (NPC) in Science: It's been quite a journey and we (Pietro Fontana, Ying Dong, Xiong Pi, Alex Tong, @pietrofn, @Ying70337209, @Sampich4) are so glad to be part of the amazing progress on NPC structures! dropbox.com/s/rlvq19wd3q1u…, science.org/doi/10.1126/sc…

7XQ8 Structure of human B-cell antigen receptor of the IgM isotype Science

Ting’s paper is out. Ting Qi Leveraging a powerful new method and large datasets, we established a comprehensive genetic regulation map of RNA splicing, which helped to reveal a distinct and essential role of RNA splicing in common traits and diseases. nature.com/articles/s4158…

Cryo-EM structure of the human IgM B cell receptor science.org/doi/10.1126/sc…

Our paper on B cell receptor is published in Science Magazine ! In this study, we determined the human IgM-BCR structure by cryo-EM. This structure reveals organizational principles of BCR and provides the basis for immunotherapy. Thank Seth Thomas Scanlon for handling our manuscript!

Researchers from Westlake University reported the fascinating structures of two prototypical human Vγ9Vδ2 and Vγ5Vδ1 TCR–CD3 complexes, unveiling distinct assembly mechanisms based on Vγ usage. Explore the intricate world of γδ TCR–CD3 complexes with us! nature.com/articles/s4158…

Here is our recent progress on T cell receptor.

Molecular mechanism of IgE-mediated FcεRI activation | Nature doi.org/10.1038/s41586…