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Uncalled4: a toolkit for nanopore signal alignment, analysis and visualization of DNA and RNA modifications. nature.com/articles/s4159…

v0.7.2 of buttery-eel has been released Mostly a bug fix release. We found a nasty bug with ultra long reads that lead to an OOM error. Decreasing the procs and batchsize keeps the issue under control. github.com/Psy-Fer/butter…

I see everyone is an expert in the Australian GST now 😆

Long reads Oxford Nanopore PacBio can provide insights into epigenetics. We (Yilei Fu Winston Timp) summarize the latest #Bioinformatics approaches to analyze methylation & why this matters! Out now Nature Reviews Genetics bit.ly/4cjxUtl BCM HGSC BCM Department of Molecular and Human Genetics Rice Computer Science Johns Hopkins University

Introducing cornetto, an adaptive genome assembly paradigm using Oxford Nanopore adaptive sampling. - greatly reduces cost per genome assembly - reference agnostic, so works for non-humans - assembly just using saliva - & many more Relies on 2 excellent software #readfish & #hifiasm.

A/Prof Jodie Ingles and A/Prof Owen Siggs spoke to 7NEWS Sydney recently about the launch of the Rare Disease Registry at Garvan. This program aims to improve diagnosis and treatment options for the two million Australians living with a rare disease. ow.ly/xtkx50VvkXH

silly question maybe, but with Minknow writing pod5 files per time interval, doesn't this mean the files start big, and get progressively smaller over time? or am I missing something? #nanopore

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Bioeng Custom Lab Hardware Turn Key Genetic Design Please RT 💚

Realfreq, a framework for real-time base modification analysis for nanopore sequencing, is now published in Bioinformatics. Written efficiently using C, a laptop can keep up with a Oxford Nanopore MinION sequencer, and a desktop a PromethION 2 solo flowcell. academic.oup.com/bioinformatics…

Just casually doing some SUP basecalling on an AMD 7900XTX GPU 😅 with ROCm in a workstation at home. A work in progress by Hasindu and Bonson in the lab.

Genomes at a fraction of the cost? Ira Deveson is speaking at #nanoporeconf to share their method, Cornetto, which has the potential to increase accessibility to sequencing human & other vertebrates' genomes due to its lower cost than existing methods. bit.ly/4ivuaq2

New postdoc opening UNSW in RNA biology and T cell immunity 🥼🧬🧫. Use molecular biology, nanopore sequencing, and in vivo models to uncover the regulatory drivers of adaptive immunity. Apply 👉 tinyurl.com/422n7hr6

Dorado is 1.0! 🎉 This London Calling release updates our DNA and RNA models to v5.2 with a new suite of mod models that are higher accuracy, lower FP rates, and significantly faster. - Introducing dorado variant 👀 - HAC error rate is down over 25%. - New 2’Ome mod models

Dorado 1.0 🚀release with new RNA modified base models for 2’Ome as well as improvement of all DNA and RNA modified base models including massive improvement in 6mA for open chromatin prediction! Also a lot more non-mods related features😆! #NanoporeConf github.com/nanoporetech/d…

Excited to announce the start of ARTIC2! 🎉 This builds on the success of ARTIC to make sequencing more equitable & accessible. EVE Group at Swiss TPH is a key team member - we'll be making sequences easier to store & share via Loculus & Pathoplexus! birmingham.ac.uk/news/2025/ambi…

Ira Deveson discusses how they are using Oxford Nanopore sequencing as a single technology to provide genome assemblies to detect complex genomic regions, providing insights into underrepresented populations, rare disease and more. #NanoporeConf

ARTIC 2 is here! birmingham.ac.uk/news/2025/ambi…

A new compression strategy to reduce the size of nanopore sequencing data. #DataCompression Oxford Nanopore #SequenceData #Bioinformatics #Genomics Genome Research genome.cshlp.org/content/early/…

Recently, I sat down with Sebastian Cocioba (Sebastian S. Cocioba🪄🌷) to chat about what real-time science can look like in practice. He spoke about his open lab-notebook, Flowers for Everyone, the necessity of documenting failures, and what it takes to run a one-man CRO today. (1/2)

Preprint on "Improving spliced alignment by modeling splice sites with deep learning". It describes minisplice for modeling splice signals. Minimap2 and miniprot now optionally use the predicted scores to improve spliced alignment. arxiv.org/abs/2506.12986