Our work predicting multiple conformations by combining sequence clustering and AlphaFold2 is in press at nature! Thrilled to get to share - now includes experimental validation for several tests of AF-Cluster, led by the incredible Adedolapo M. Ojoawo! go.nature.com/49uCNxU

The Praetorius lab ISTAustria is looking for PhD students in 2024. If you are interested in protein design at a great institute near Vienna reach out to me! dropbox.com/scl/fi/6iny2zs…

Early access to our paper nature is live! Lots of new ideas in here - rational parametric design to new ways of applying RFdiffusion (including a new model). Lucky to have worked with Susana Vazquez Torres Phil Leung, collaborators Institute for Protein Design and beyond. Longer thread soon 🙂

Today in nature we compare several compositions of AI-based and classical methods of peptide binder design to make binders to nine different physiologically relevant hormones and cell signaling peptides: nature.com/articles/s4158… Work led with Susana Vazquez Torres and Preetham Venkatesh

Special thanks to Joseph Watson , Joseph Rogers , and David Baker for their invaluable input and supervision. Dedicating this work to aspiring female scientists, especially in Latin America. My dream is to see more of us thriving in the world of science. ¡Vamos por más!

A huge congratulations to Susana, Phil, Preetham and the rest of the team! It was such a pleasure being involved in a project that brought together a whole range of approaches and people to make big progress on an important problem!

Was a delight to witness the development of these amazing helix-binding proteins. Congratulations to Susana Vazquez Torres Preetham Venkatesh Phil Leung Joseph Watson and all on the team from the David Baker lab. nature.com/articles/s4158…

Expanding protein pore palette beyond biology. Computational design of protein pores with various shapes and sizes. (Potential applications: Nanopore sensing, DNA/Protein sequencing, Custom pores for selective membranes and ligand-gated channels for cellular delivery.....)

Engineered cells intelligently sense and respond to their environments with desired behaviors. We showed that de novo-designed protein binders can expand the sensing capabilities of 3 synthetic receptors, enabling new targets for engineered cells. biorxiv.org/content/10.110…

I had the opportunity to take Prof Mahadevan's molecular biology course at IISc, and remember him fondly as a brilliant and kind teacher. This personal essay by him is moving as it highlights his life behind the scenes.

Paper is now live on Science Magazine! Congrats to Rohith Krishna Jue Wang Woody Ahern for leading this work. Big leap for protein modeling and design! Paper: science.org/doi/10.1126/sc… Code: github.com/baker-laborato…

We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!

Super excited to share our paper “Design of amyloidogenic peptide traps” is out now! 🧠 nature.com/articles/s4158… Special thanks to Ewa Andrzejewska , Danny Sahtoe and David Baker

Really cool to see the huge engagement surrounding AlphaFold 3 and the structures scientists are posting. We’re working to release the AF3 model (incl. weights) in the next 6 months for academic use, so it won’t depend on our research infra. Also the AFServer job limit is now

OpenFold paper is now out in Nature Methods. Timely. I’ll say more about AF3 at the end of this thread, but first I wanted to highlight what’s new since our initial release. (1/9)

I'm very excited to share the work I've been doing over the last year! Contributing to new therapies for snakebite victims and collaborating with amazing scientists has been incredible! researchsquare.com/article/rs-440… Timothy Jenkins Institute for Protein Design

Not many people will read your PhD thesis, but if you completed your doctoral research at the ANU College of Science, then Tabitha Carvan has probably read one small part of it – the acknowledgements. What she found is a kind of poetry in the science. science.anu.edu.au/news-events/ne…

Met some really cool people through 5050 and the folks at 50Y are very passionate about supporting you throughout the program and after! Would encourage anyone thinking about entrepreneurship to apply and happy to chat if you have questions

Congrats Linna and team! Amazing work designing small-molecule binders using shape complementary pseudocycles and turning them into sensors.