Excited to share our latest preprint delineating how activation of the Mis18 complex by the PLK1 phosphorylation cascade ensures centromere inheritance. biorxiv.org/content/10.110… Pragya Srivastava Bethan Medina-Pritchard Alba Abad JP Arulanandam WTCCB Cell Biology Biological Sciences | University of Edinburgh Gene Center Munich.

Check out our latest work on the epigenetic inheritance of centromeres: biorxiv.org/content/10.110… We demonstrate that PLK1 unlocks a conformational change of MIS18α to license the recruitment of HJURP in early G1 phase. Delighted to see our findings reproduced by the JP Lab !

Excited to share our work showing how PLK1 licenses CENP-A deposition at centromeres to ensure centromere inheritance WTCCB Cell Biology Gene Center Munich Biological Sciences | University of Edinburgh Universität München Pragya Srivastava Bethan Medina-Pritchard Alba Abad Paula Sotelo European Research Council (ERC) dhafer ben khalifa & MRC science.org/doi/10.1126/sc…

Also check out a parallel study with similar findings from the Musacchio lab Andrea Musacchio Musacchio Lab Duccio Conti science.org/doi/10.1126/sc…