1/2 Engineered human mitochondrial DNA (mtDNA): Yi Fu, Max Land et al. did it in biorxiv.org/content/10.110… and it's absolutely wild. For context, in contrast to the tech available to manipulate our nuclear genome, we've barely touched human mtDNA. Following recent advances in

2/2 The authors used a bold cross-kingdom synthetic biology approach in which they employed machinery from Mycobacterium and T4 bacteriophage to enable EJ. Using single-cell multiomics (DOGMA-seq, as developed by Eleni Mimitou, Caleb Lareau, Kelvin Chen et al.), they uncovered

I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in nature. nature.com/articles/s4158… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9

🎉 Congratulations to all the #iGEM2024 Grand Jamboree finalists! Your hard work and innovation to push the boundaries of biotechnology are truly inspiring. A special shout-out to Cultivarium-sponsored Overgraduate finalists, iGEM Marburg 2024 and iGEM Team Aachen ! 🙌 #worldexposynbio

Written by Liyam Chitayat Read the essay and subscribe! press.asimov.com/articles/mitoc…

Over the years, people have asked: What does Asimov do? This is our brief response. At a high level, we think biology is an advanced form of molecular nanotechnology. Our goal is to create tools and software to more reliably engineer cells, thus bolstering humanity’s ability to

New in nature: Analysis of 56,434 human mitochondrial genomes through a constraint model for mtDNA. It reveals which positions are highly constrained - that's a huge advance in our understanding of pathogenic variants and mitochondrial disease. Importantly, though, it's also an

Top altmetrics score 2024: #16🏆✨ Nils-Göran Larsson (Karolinska Institutet) and co-authors describe how inhibition of mitochondrial transcription reduces #OXPHOS capacity but increases fatty acid oxidation in the #liver, protecting against #obesity🧫🐭 nature.com/articles/s4225…

A human metabolic map of pharmacological perturbations reveals drug modes of action go.nature.com/3CreANg

NIH grants frozen. Discoveries delayed. PhDs pushed out. Academia getting gutted. Innovation must continue. There’s never been a better time for scientists to build startups.

Here we go!! We’re hiring a Computational Scientist and an Experimental Biologist to join our fast-paced platform therapeutics startup! We need scientists and engineers who own their work, adapt quickly without losing precision, and stay laser-focused on what truly matters. We

Technically challenging and historically siloed from broader genomics and therapeutic innovation, mitochondrial biology is now at the center of converging tools, data, and demand. We are incredibly excited to see Nathan Wolfe and ARIA opening up an opportunity space in

Happy #NewMemberMonday! 👩‍🔬 Powerhouse Biology makes precision peptide therapeutics to combat mitochondrial dysfunction 💡 serna bio leverages AI to discover RNA-targeting small molecules 👨‍🔬 Telix Pharmaceuticals drives radiopharmaceutical innovation from its base in Australia

Thanks to everyone who joined our AI x Bio workshop this weekend! 180 scientists, entrepreneurs, engineers, and funders gathered to explore how AI can accelerate longevity research. The workshop included presentations on the current state of the field and its biggest

First data in!! We've transferred into the brand-new office and laboratory space at MBC BioLabs in San Carlos! Huge thanks to the MBC team for moving mountains to get us (and many others) to work, and to Leica Microsystems for helping us hit the ground running with core equipment and

We can't wrap our head around how she does it all - our champion CSO RachelMarie804 just published "The AI drug revolution needs a revolution" in npj Drug Discovery. Rachel co-founded Powerhouse Biology with a vision to implement AI-guided multi-modal analysis of mitochondrial

Life is beautiful. We want to give people more of it.

Few things solidify a reputation better than a sticky nickname. 68 years ago this month, Philip Siekevitz called the mitochondrion “a small body which appears to play a central role in the oxidation of foodstuff,” and popularized its now iconic title: the powerhouse of the cell.

First day on site! aru joined Powerhouse Biology as a Computational Scientist. He’s our trailblazer on multi-modal network models and ML analysis, and he’s set to grow and shape our computational team. We were instant fans: his creative spark and bold move (yep, he

On Powerhouses and Foodstuff: in this delightful primer in Life Sciences Insights, a California Life Sciences (CLS) magazine, co-founder and CSO RachelMarie804 explains why we do what we do at Powerhouse Biology. Have a read on how we use high content data to resolve multidimensional,