A systematic investigation of 20S #proteasome substrates reveals 100s of substrates & differential functionality of naïve and oxidized 20S proteasome complexes ➡️ embopress.org/doi/full/10.10… Picotti Lab IMSB_ETH Michal Sharon Weizmann Institute #proteomics #massspectrometry

Our paper with Michal Sharon is now live Mol Syst Biol. We identified hundreds of substrates of the 20S proteasome, enriched in RNA- and DNA-binding proteins with IDRs. A variety of substrates showed site-specific cleavage, suggesting functional products. embopress.org/doi/full/10.10…

So happy to see our work published at Cell ! We added the quaternary structure dimension to proteome-wide, #AlphaFold2 predictions: The published paper: sciencedirect.com/science/articl… The original 🧵 (Two more experimental structures since!) x.com/ElevyLab/statu…

The paper by Korkhov Lab, together with Picotti Lab, Alexander Leitner and Federico Uliana, now out in EMBO Reports, describes the cryo-EM- and structural proteomics-based analysis of adenylyl cyclase AC8 and its macromolecular complexes. More: biol.ethz.ch/en/news-and-ev…

Publication by the Allain & Leitner Labs (IMSB_ETH, ETH Zurich) with 1st authors Tebbe de Vries & Mihajlo Novakovic (@tflut1,Mihajlo Novakovic) "Specific #protein-#RNA interactions are mostly preserved in biomolecular #condensates" Science Advances bit.ly/4cfo0sb #MS #LLPS

Great talk by Tetiana Serdiuk at the AD/PD conference on biochemical differences between amyloid strains linked to different alpha-synucleinopathies. AD/PD - Advances in Science & Therapy

Our warmest congratulations to Franziska Elsaesser on the successful defense of her PhD. Excellent job, Franzi!

N&V by Seth S. Margolis on the study by Picotti Lab & Michal Sharon developing an advanced #proteomics method (PiP-MS) to comprehensively explore 20S #proteasome substrates in the human proteome ➡️ embopress.org/doi/full/10.10…

Exciting development for 🇨🇭 research! Following a three-year hiatus, scientists from Switzerland can now participate in the 2024 ERC Advanced Grants. The ETH Board wishes that this solution can be extended to all 2025 calls in summer 2024. #HorizonEurope

High resolution protein complex analysis beyond AP-MS by the Gstaiger group: nature.com/articles/s4159…. Nice collaborative adventure at IMSB_ETH from the @MGstaigerlab members @FabianFrommelt , Andrea Fossati , Federico Uliana and from Bernd Wollscheid lab members

Congratulations, Albert. An exciting research area you are pioneering. We look forward to exciting discoveries ahead.

Thank you European Proteomics Association for the JPA Proteome Pioneer Award in recognition for our group's work in this field. The award promotes "the principles of sharing and integrating resources for the development of excellent research" which is something we do strive for.

Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out Nature Biotechnology ! Read here👉: doi.org/10.1038/s41587… 🔬 Highlights: - Uses an experimental library of peptide markers integrated with a structural proteomics workflow. -