Hi Friends, I added my latest plasmid to my shop if anyone wants to pick up a stab and try it out. All my plasmids are $20 a pop until the heat death of the universe and fully open source. No strings or MTA. Just give us a shoutout in your pubs if you can! atinygreencell.com/products/pidmv…

I’m the youngest on my team. During my group meeting I referred to myself as very demure and mindful. Everyone just stared blankly at me. :(

How do I reach out to my grad school mentor who I haven’t spoken to in 4 years that he was wrong about an antibiotic being bacteriostatic, causing me to tell others for years the same thing until I learned that it is in fact bactericidal? He made me lose my science street cred.

Setting your phone down on the floor of a public toilet is absolutely foul. Right to jail.

I am working with an IRES construct for the first time. I transformed in DH5a yesterday and after 24h the colonies have barely grown. Does anyone know if this is standard for IRES? In comparison, I have a 2A construct that has pickable colonies.

De novo protein design is great, but nature has millions of proteins- why not repurpose them? Introducing Raygun, a new approach to protein design. It allows you to miniaturize, magnify or modify any protein. We synthesized miniaturized variants of eGFP and mCherry! 1/

I had a distinguished looking gentleman throw himself in front of an elevator door to keep it open for me. Something awakened in me. I need this to happen more.

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…

Our work on computational design of intrinsically disordered proteins is now out in Science Advances We asked whether we could use molecular simulations and ML to design disordered proteins with specified properties of conformational ensembles 🍝 doi.org/10.1126/sciadv…

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

“Come to br—”

Had a guest stay the night. All before 7 AM while I was asleep, they managed to: shower and use my personal towels, use my loofah, douse themselves in my perfumes, steal my socks, steal my shoes, steal my underwear. Couldn’t get them out the door fast enough.

AlphaFold3 reproduced and params/code released. 🤩

The final version of our paper on anti-CRISPRs "in disguise" as Cas proteins is out today in Nature! Congrats to Mark, Edith and the whole team! nature.com/articles/s4158…

Once again I have found myself accidentally making chlorine gas in the lab. 🧍🏻

We’re excited to introduce @ChaiDiscovery and release Chai-1, a foundation model for molecular structure prediction that performs at the state-of-the-art across a variety of drug discovery tasks We're releasing inference code, weights & a web interface: chaidiscovery.com/blog/introduct…

Money isn’t an issue for me. It’s a problem.

I love how every scientist on my feed immediately made the same joke about "I have a concept of a plan"