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In this study, Tye et al show how RIPK3-caspase-8 signaling induces inflammation to drive MAFLD, while MLKL noncanonically regulates lipid accumulation and metabolism to drive obesity and MAFLD. Kate Lawlor CiiiD Hudson Hudson Institute of Medical Research WEHI (Walter and Eliza Hall Institute) life-science-alliance.org/content/8/1/e2…

Very proud & excited to be socialising our preprint uncovering new mechanisms of epithelial cell death in IBD! Massive 4-year collab across WEHI (Walter and Eliza Hall Institute) & @RMH. Big thanks to the patients involved in this study and support from @NHMRC & Kenneth Rainin Foundation biorxiv.org/content/10.110…

Tirzepatide for Obesity Treatment and Diabetes Prevention | New England Journal of Medicine nejm.org/doi/full/10.10…

The Walczak Lab did it again and with great news to us all, FasL blocker clinical trial for severe #COVID-19 (and maybe other future airway viruses ? ). Congratulations to everyone involved in this fantastic achievement

Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway: Molecular Cell cell.com/molecular-cell…

Nieves Peltzer: una vita tra ricerca, famiglia e la sua amata Magliano incontrinotizie.it/nieves-peltzer…

Happy to announce a new PhD from the Peltzer Lab. Dr. Önay Veli congratulations on this wonderful achievement. We are levitating, so proud we are of you!!! SFB_1403 CECAD Cologne Universität zu Köln

NO QUEDARÁ NADA (del sistema científico argentino) nature.com/articles/d4158…

Proud to share three papers from our lab rdcu.be/d2hUm, Anthony Letai MD PhD rdcu.be/d5rb3, and R. Bernards The Netherlands Cancer Institute rdcu.be/d5rjW all showing predictable mitochondrial control of senescent cell death, using BH3 profiling as a biomarker for senolytic therapy

Thrilled to start 2025 with our latest findings! Felicia Chan Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive cell.com/cell-reports/f…

Amazing study by Kate Lawlor and team showing an implication of Mlkl in controlling liver lipogenesis. Congratulations!!!

You just can't leave the dessert even though you're full? 🍰 Blame it on your POMC neurons!🧠 (details ➡️🧵) Congratulations to Marielle Minère, Henning Fenselau and all other authors for their newest publication Science Magazine ! 🎉 science.org/doi/10.1126/sc… 1/3

🆕🆕🆕Preprint from our labs doi.org/10.1101/2025.0… In this brief report, we evaluated various macrophage coculture systems for their CLL-feeding potential, phagocytosis capacity, induction of treatment resistance, and their impact on the transcriptional profiles of CLL cells

‼️📢 paper alert! Check out the beautiful study by Uris Ros and Ana Garcia Sáez on the regulation and targeting of necroptosis (Mlkl)! Molecular Cell #necroptosis #celldeath

Another great meeting coming up this year! aegeanconferences.org/src/App/confer… Tom Luedde

Amazing day of science during the #SRCSB day, closing with the #ErnstDieterGillesAward to the one and only Uri Alon for his pioneering and outstanding contributions to #systembiology and #systemsmedicine fields

When in the presence of genius, just swing it! Uri Alon delivering his keynote lecture. One of the most inspiring lectures I had witnessed. Thank you!

Great conversations with wonderful Stefanie Bader in uni Stuttgart. For a future of great science ahead!