Next episode releases today at 3PM MST. We will be discussing glycation and its interaction with hormones. If you’ve been trying to understand metabolic health, this is an important piece of the puzzle.

New episode released today. Glycation does not just affect aging — it interacts directly with your hormones. If you are trying to understand metabolic health, this connection is essential. Watch here: youtu.be/J7hJNQyMHR4

I think of glycation and oxidation as metabolic twins. They often travel together, reinforce each other, and are both driven by the same root cause: chronically elevated glucose and the insulin dysfunction that follows. Treating one without addressing the other is incomplete.

Hormonal imbalance is often treated in isolation. But physiology does not work that way. Glycation can influence hormonal signaling in ways that are rarely discussed. This is where that conversation begins: youtu.be/J7hJNQyMHR4

If you are addressing hormones without considering underlying biochemical stress, you may be missing part of the picture. Glycation is one such stressor. It operates quietly, but its effects are measurable. Learn more here: youtube.com/@paulreynoldsp…

Something that surprises people: inflammation causes insulin resistance just as much as insulin resistance causes inflammation. It's a true bidirectional loop. AGEs activate RAGE, RAGE drives NF-κB, NF-κB produces pro-inflammatory cytokines, and those cytokines impair insulin

One of the challenges in health is that cause and effect are not always obvious. Glycation is a gradual process — but it can influence systems like hormones over time. Understanding that relationship changes how you approach health: youtu.be/J7hJNQyMHR4

Your kidneys are among the first casualties of chronic glycation. The glomerular basement membrane, the filtration barrier in the kidney, is collagen-rich and extremely long-lived. Glycated collagen there thickens and stiffens the membrane, reducing filtration efficiency. This is

We often look for immediate explanations for symptoms. But many processes in the body are cumulative. Glycation is one of them — and its interaction with hormones is underappreciated. This is worth examining: youtu.be/J7hJNQyMHR4

There's a reason some people call Alzheimer's Disease "type 3 diabetes." A hard sell... The neurons of the brain are extraordinarily glucose-hungry, and when insulin signaling in the brain breaks down, neurons lose their primary fuel source. Add to this the direct neurotoxicity

Cooking method matters more than most people think when it comes to dietary AGEs. Boiling and steaming generate far fewer AGEs than excessive grilling, frying, or roasting at high heat — even with the same food. The Maillard reaction that creates that delicious browning? That's

If you are interested in long-term metabolic health, you need to look beyond surface-level markers. Glycation provides a different lens. One that connects multiple systems, including hormones. Start here: youtube.com/@paulreynoldsp…

Next week’s discussion will explore a different question: What if your mouth reflects your metabolic state more than you realize? Glycation may offer part of that explanation. New episode tomorrow.

One reason low-carb diets are so consistently effective at reducing inflammatory markers isn't just about weight loss. Lowering dietary carbohydrate directly reduces glucose exposure, which reduces the rate of glycation, which reduces the AGE burden driving chronic inflammation.

New episode releases today at 3PM MST. Glycation and your mouth as a metabolic indicator. If you are paying attention to early signals in the body, this will be relevant.

Your body has a natural defense against glycation: an enzyme system called glyoxalase. It detoxifies methylglyoxal, one of the most reactive glycating agents the body produces. But this system gets overwhelmed under conditions of chronic hyperglycemia. One more reason that

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New episode released today. Your mouth may be one of the earliest indicators of metabolic dysfunction. Glycation does not stay hidden — it often shows up in places people overlook, including gum health. Watch here: youtu.be/YeK5vtwNKfo

Gum disease is typically treated as a local issue. But biology does not work in isolation. There may be underlying metabolic processes contributing to what we see in the mouth. Glycation is one of them: youtu.be/YeK5vtwNKfo

The lens of your eye is the only tissue in the body that never turns over its proteins. The crystallins in your lens are with you for life. This is exactly why cataracts are a hallmark of diabetes — glycated crystallins aggregate and cloud the lens over decades. It's glycation in