Calling all biochemists & molecular biologists! The ASBMB Discover BMB 2025 call for speakers is open. Consider applying here: discoverbmb.asbmb.org/call-for-speak…

biorxiv.org/content/10.110… I am thrilled to see our pre-print out and available to the scientific community. Co-led by Abby Bartlett, we identify two mammalian enzymes that drive the catabolism of 4-hydroxy acids through FAO via 4-phosphoacyl-CoA intermediates. #lipids #metabolism

One-hour phosphoproteome analysis with the Orbitrap Astral mass spectrometer

Enabled by new instrumentation, we report nearly 40k localized phosphosites in one hour and the deepest mouse phosphoproteome to date with only 12 hours of instrument time
biorxiv.org/content/10.110…

☕️In this issue: Pagliarini Lab & co show that Hem25p (a glycine transporter required for #haem biosynthesis) is also needed for #isopentenyl pyrophosphate transport into #mitochondria and #CoenzymeQ synthesis in fungi.
rdcu.be/dozIl
nature.com/articles/s4155…

Rachel Guerra and I were happy to write this Nature Chemical Biology News & Views highlighting the recent work by Park, Rhee et al. on RTN4IP1/OPA10 as an oxidoreductase for coenzyme Q synthesis!
nature.com/articles/s4158…
nature.com/articles/s4158…

I think it’s really funny that my X account thinks Oleh keeps posting “sensitive content.” What kind of racy mitochondrial content am I missing?!

I’m pleased to share our new work on the mitochondrial phosphatase PPTC7 led by Natalie Niemi! Check out the important roles this protein plays in mitophagy and metabolic regulation.

#mitochondria
nature.com/articles/s4146…

Excited to share our new discovery of a mitochondrial isoprene transporter published today in Nature Cell Biology and led by Jonathan Tai! Interesting example of transporter dual functionality.

#Mitochondria
nature.com/articles/s4155…

What a testament to the power and importance of basic scientific inquiry!

I second that, Scot! Stay tuned for more to come from Zak Baker. We'd like to keep him this side of the border, but he'd be a gem for any Canadian University.

Happy to share our new mitochondrial proteome research review out today in Nature Reviews Molecular Cell Biology led by Zak Baker and Patrick Forny. The field has come a long way in the past 20 years, yet plenty of exciting new things to do!
nature.com/articles/s4158…
rdcu.be/dnmm3
#Mitochondria

If you like #genetics in human cells you may enjoy our latest paper by Gianluca Talevi and collaborators.
A ‘fishing expedition’ using logic as our guide by Gian-Luca McLelland to study triglyceride synthesis. After some plot twists it yields DIESL!
nature.com/articles/s4158…

Very happy to see our paper published. Thanks to all coauthors for a very nice collaboration!

Congratulations to Judith Simcox PhD, who has been awarded the Walter A. Shaw Young Investigator Award in Lipid Research from ASBMB, recognizing her outstanding research contributions in the area of lipids! biochem.wisc.edu/2023/08/21/sim…

Out today nature – our analysis of the influences of common nuclear DNA variation on mitochondrial DNA copy number and heteroplasmy across >250,000 people across two biobanks! disq.us/t/4ibyjjo

The FNIH proudly names Navdeep S. Chandel, PhD, and Vamsi Mootha, MD, recipients of the 2023 Lurie Prize in Biomedical Sciences for their groundbreaking research in mitochondrial science.

Read the full press release here bit.ly/3qgLWIQ

CoQ10 is large and very hydrophobic, which limits its bioavailability. Our new study, led by Laura Steenberge, shows that CoQ4 is a sufficient substitute for multiple CoQ functions in cells and can be targeted to mitochondria. biorxiv.org/content/10.110…
#bioRxiv
#mitochondria
#CoQ

The 5th #CSHAsia meeting on #Mitochondria & #Metabolism in Health and Disease will be held at Suzhou, 'Full in-person' this time, in Oct 30-Nov 3, 2023. Register via csh-asia.org/?content/1334
#ATP #mtDNA #Mitophagy #Inflammation #Aging #apoptosis #Caspase #Signaling #homeostasis

I had my shoes shined (badly needed) at the Minneapolis airport today by a 94-year-old legend of a WWII vet named Paul. I asked him if he had any dietary secrets. “Nah, I eat EVERYTHING.” And also does karate and “teaches dancing.” Humbling. #metabolism

Mitochondria need isoprenoids from the mevalonate pathway to make CoQ, but how do they access them from the cytosol? Check out our surprising finding that Hem25p doubles as an IPP transporter.
#mitochondria
#CoQ
Hem25p is a mitochondrial IPP transporter biorxiv.org/content/10.110…