🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Excited to share our latest, a wonderful collaboration with Cigall Kadoch Kadoch Lab, using positive-selection CRISPR screening to show that Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer biorxiv.org/content/10.110….

Back to back preprints showing mammalian SWI/SNF complexes regulate the transcription factor POU2F3 & represent a therapeutic vulnerability in small cell #LungCancer 1st, OserLab Cigall Kadoch biorxiv.org/content/10.110… 2nd, Arul Chinnaiyan Christopher Vakoc biorxiv.org/content/10.110… (This

New preprint from Monte Winslow's Lab Stanford Cancer Institute Modeling the genomic complexity of human cancer using Cas12a mice biorxiv.org/content/10.110… Ability to rapidly generate #LungCancer #PancreaticCancer with multiple tumor suppressor gene losses driven by Cas12a-directed guides (Smad4,

If you like to read final versions - this was just posted: Commentary on SMARCA4-deficient undifferentiated tumors mimicking small cell carcinoma. doi.org/10.1158/1078-0… Original paper by Sutherland Lab and Jin Ng, PhD doi.org/10.1158/1078-0…

Today’s U.S. FDA approval is a landmark achievement in the evolution of small cell lung cancer care - demonstrating Amgen 🧪🔬🧬’s continued success against the toughest cancers and reaffirming our commitment to relentlessly innovating for patients. #MyCompany

A study in Cancer Cell, led by Matthew Oser, MD, PhD (OserLab) & Cigall Kadoch, PhD (Cigall Kadoch) at @danafarber identify SWI/SNF inhibitors as a potential targeted treatment for POU2F3-positive small cell lung cancer, accounting for 12% of cases. Study ▶️ ms.spr.ly/6016lRrkI

Thank you Dana-Farber News for featuring our new work, a wonderful collaborative effort with Cigall Kadoch Kadoch Lab, published today in Cancer Cell. Congrats to Leslie Duplaquet and Kevin So who together led this study and to computational biologist Alex Ying.

Excited to see our collaborative work with OserLab Dana-Farber Dana-Farber News on #SCLC #lungcancer out in Cancer Cell, identifying chemically targetable #BAFcomplex chromatin regulatory dependencies and providing foundation for new clinical studies for this aggressive cancer.

Exciting to see our Kadoch Lab and OserLab collaborative study focused on mSWI/SNF chromatin remodeling complexes in small cell lung cancer out in Cancer Cell! This is one of 4+ studies published/soon to be published highlighting the potential for #BAF disruption in SCLC!

Thrilled to visit MD Anderson Cancer Center next week and present some recent work from our lab on SCLC. Thank you Xiuning Le MD PhD for inviting and hosting me!

Thoracic oncologist Matt Oser OserLab, and scientist Cigall Kadoch, Kadoch Lab at Dana-Farber have discovered a way to stunt the function of a driver of small cell lung cancer. The finding points to a potential treatment (cont) ms.spr.ly/l/6012mpPpQ

I am very excited to announce that I have started my lab at the Brigham and Women’s Hospital and Harvard Medical School in the Department of Pathology. We are seeking talented, curious, individuals and recruiting at all levels! tsailab.bwh.harvard.edu 1/2

Great talk by Dr. Shilpa Singh OserLab Dana-Farber looking at Cyclin A/B RxL Macrocyclic Inhibitors in SCLC w/ high E2F activity. Beautiful example of bridging lab to clinical research. Phase 1 trial is recruiting. #SCLC25 SmallCellSMASHERS