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#New #BasicScience in #OAC Tao et al demonstrates that macrophages regulate nucleus pulpous cell ECM expression in intervertebral disc degeneration (IDD) through the OPN-CD44 axis! 🧪 🔗 buff.ly/kYHdHun

Thank you for attending the #OAC and #OACO journal session today at #OARSI2025 Highlights include the announcement of our Papers of the Year, Reviewers of the Year, and the Biostatistical Methods session! ProfDavidHunter AM Malfait

Early Career Investigators, are you interested in Peer Review Training? 🤩 Applicants must be a member of OARSI and have completed at least 2 years of a Master’s, PhD, MD or equivalent degree. If you are interested please fill out this poll by May 2nd. lnkd.in/ehyCNwnx

May is upon us 🪷 🌷 🌼 And with that a new #EditorsChoice #BasicScience in #OAC This month learn about mechanical stress, PIEZO1, the cGAS-STING pathway and its contribution to cartilage degradation in #OA! buff.ly/4fYDGC7

🚨 New #EditorsChoice Infographic 🚨 Are "healthy" joints really healthy? This study found that some might have a predisposition for general cartilage deterioration highlighting the #systemic nature of hand #osteoarthritis Read more from Alexander Mathiessen: doi.org/phqf

🎉 NEW this month! Very low certainty of modest and short-term effects of #radiofrequency ablation for knee #OA Read more from ProfDavidHunter vicky duong Bruno Saragiotto Leticia Deveza at - oarsijournal.com/article/S1063-…

⚡ New this month Osteoarthritis and Cartilage Journals 🚨 This identified distinct pain phenotypes in people at risk of knee that is another step towards more comprehensive management of #OA symptoms 🆓 Read for free at oarsijournal.com/action/showPdf…

😍 New this month! 🦴 Bone remodeling responses throughout subchondral bone contribute to the #kneepain experience Read more from Boston U Chobanian & Avedisian School of Medicine at oarsijournal.com/article/S1063-…

🤩 Just out this month! 3.5% ➡️ The low prevalence of primary #cam morphology (PCM) in early adolescents suggests that PCM gradually develops over time #netherlands 🇳🇱 Read more from Chen et al. - lnkd.in/gjQwjgD7

🍞 Fresh in this month's issue! Arthroscopic partial meniscectomy (APM) 📉 Worsening #bonemarrowlesions and cartilage defects with APM compared to #physicaltherapy with optional delayed-APM at 2y Read more from Sabine van der Graaff et al. - doi.org/pkbf

New this month in #OAC for #BasicScience Learn about how the CRLF1/CLCF1 heterodimer is involved in IVDD via exacerbation of ECM degradation and nucleus pulposus cell senescence🧪 sciencedirect.com/science/articl…

Beta-defensin 1 (DEFB1), is involved in inflammation, cell apoptosis and senescence. In a disk degeneration model, DEFB1 knockdown ameliorated IDD features. Targeting DEFB1 could be a promising therapeutic strategy for IDD.🧐 Read more: oarsijournal.com/article/S1063-…

In this #New #BasicScience in #OAC learn how EZH2 inhibits senescence-associated inflammation and attenuates intervertebral disc degeneration by regulating the cGAS/STING pathway. Read more 🔗 sciencedirect.com/science/articl…

🚨 NEW 🚨 🤩 This month's Editors Choice (Clinical) is about intestinal health and hand #osteoarthritis Read more from Binvignat et al - oarsijournal.com/article/S1063-…

🆕 New in this month’s issue 📚 Structural knee MRI findings common in asymptomatic adults as young as 33 years old Read more from Kemppainen et al - oarsijournal.com/article/S1063-…

🤩 New paper 👀 This review of 6 RCTs found that #methotrexate improves pain and functional recovery in knee OA without minimal safety concerns Read more about methotrexate from Wong et al. oarsijournal.com/article/S1063-…

🥰 New this month! #kneecrepitus Read all about the utility of KOOS item S2 in assessing knee crepitus (Do you feel grinding, gear clicking or any other type of noise when your knee moves?) More from Jamon Couch et al at oarsijournal.com/article/S1063-… OARSI Early Career Investigators La Trobe SEMRC

Just out this month! How well do hyaluronic acid (HA) injections work for knee osteoarthritis (OA), and who benefits most? Read more from Cao et al. - oarsijournal.com/article/S1063-…

🚶🚶‍♂️Read all about #walking and structural changes in the osteoarthritic knee in this new study by Sara and colleagues: oarsijournal.com/article/S1063-…

#BasicScience #EditorsChoice for #June 🤩 This work aimed to elucidate the role of Wnt signaling in the mechanoresponsiveness of healthy and osteoarthritic human cartilage. Rik Lories Nuria Viudes Sarrión Silvia Monteagudo ilse jonkers Read more: lnkd.in/eRiKjiQQ