You could pay every American $3,000 on the money that the wealthiest 0.0002% have *increased* their wealth by during the pandemic -__-

New data from the BioFINDER suggest that enlarged perivascular spaces, which previously have been implicated in AD+pathological #aging, are related to small vessel but not #Alzheimer disease or cognition:bit.ly/35vU7CA Neurology Journal Oskar Hansson Niklas Mattsson-Carlgren

Excellent review about #APOE ε2: "Protective mechanism and therapeutic implications for #Alzheimer’s disease", bit.ly/2TZWJTO. Can we develop therapies that mimic APOE ε2 effects to prevent/delay/cure AD?

Plasma P-tau depends on both beta-amyloid and tau pathology in Alzheimer's disease. Early in the disease, plasma P-tau may be increased in response to beta-amyloid pathology. In later disease stages, plasma P-tau is associated with tau aggregation in the neocortex.

In this paper, we demonstrate how plasma and CSF biomarkers can be used for individualized prognostication of cognitive decline due to Alzheimer's disease. We hope that this will improve patient management, help patients and families, and speed up drug trials for new therapies.

Plasma phosphorylated tau (P-tau) correlate with imaging measures of brain atrophy over time in AD! Perhaps repeated blood tests can track atrophy, both in clinical practice and in drug trials, to find therapies that reduce degeneration? doi.org/10.1002/acn3.5…. BioFINDER

Very happy to present this work on Time Between Milestone Events in The Alzheimer's Disease Amyloid Cascade doi.org/10.1016/j.neur…. One key finding was that changes in tau started quite early. Perhaps DMTs must be initiated prior to significant Aβ pathology? BioFINDER

In this proteomics study rdcu.be/cdX7P we found evidence of accelerated inflammatory ageing in Alzheimer's disease, supporting the view that inflammatory pathways are critically involved in Alzheimer's disease BioFINDER @LuWcmm Oskar Hansson

I am delighted to share our latest blood biomarker work published in Alzheimer's Association. We investigated baseline & longitudinal #pTau, #NfL, #GFAP, #tTau, #Aβ to predict diagnosis & grey matter changes in individuals not predetermined by CSF/imaging. alz-journals.onlinelibrary.wiley.com/doi/full/10.10… 1/n

Our recent paper shows that plasma pTau is mainly related to amyloid plaques in early disease and tau tangles in later disease stages. That is, soluble pTau is associated with both pathologies and not simply a marker of any of these pathologies per se. doi.org/10.15252/emmm.…

Great collaboration evaluating plasma pTau in two cohorts characterized using either neuropathology (Banner) or PET (BioFINDER). Especially thanks to Niklas Mattsson-Carlgren. MultiPark at LundU Lund University

In this new paper doi.org/10.15252/emmm.…, we show how changes in levels of soluble phosphorylated tau depend on deposition of both beta-amyloid and tau aggregates in the brain in Alzheimer's disease BioFINDER EMBO Mol. Medicine

Research in progress in one of our research groups. Niklas Mattsson-Carlgren Roman Sattarov #researchinprogress #phdlife #neuroscience #operetta #experimentalresearch #biomarkers #inducedneurons

Findings from BioFINDER reveal genetic influence on longitudinal #cognitivedecline in early stages of #AD, partially mediated by #Abeta pathology. Scientific Reports Sebastian Palmqvist Oskar Hansson Niklas Mattsson-Carlgren @Medfak_LU rdcu.be/czgt1

80 % of the world’s #HighlyCitedResearchers at #lunduniversity comes from MultiPark. Congratulations to Oskar Hansson Sara linse and Niklas Mattsson-Carlgren. And to Patrik Brundin MD PhD, previously initiating MultiPark. @Medfak_LU #Clarivate multipark.lu.se/article/majori…

Does #Abeta38 affect the risk of #AD ? Alzforum discusses interesting findings by Nicholas Cullen, Niklas Mattsson-Carlgren, Sebastian Palmqvist and Oskar Hansson. #neuroscience #biomarkers #alzheimersdisease @Medfak_LU

Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and FTLD. Class II evidence. bit.ly/3K0hWFf Niklas Mattsson-Carlgren Lea T. Grinberg, M.D, Ph.D RikOssenkoppele Alexander Ehrenberg Salvo Spina Julio C. Rojas @relajoie @leoiacca Oskar Hansson ALBA Language Neurobiology laboratory @RabLab_UCSF

Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and FTLD. 101 patients w/ CSF & neuropath data. bit.ly/3K0hWFf Niklas Mattsson-Carlgren Lea T. Grinberg, M.D, Ph.D RikOssenkoppele Alexander Ehrenberg Salvo Spina Julio C. Rojas @relajoie @leoiacca Oskar Hansson @RabLab_UCSF

Enjoy this podcast episode about our recent Neurology paper on CSF biomarkers in autopsy confirmed neurodegenerative diseases! player.fm/series/neurolo… BioFINDER Oskar Hansson @RabLab_UCSF

Check out this paper, a collaboration between Lund University and UCSF Memory and Aging Center, where we show that CSF biomarkers have very high accuracy for autopsy confirmed Alzheimer's disease n.neurology.org/content/98/11/… Oskar Hansson @RabLab_UCSF MultiPark at LundU BioFINDER