Finally, a man-made catalyst for gamma methylene CH! Double bond and carbonyl alpha chemistry build 1,2-relationship well, now via beta and gamma CH , we provide new disconnections for 1,3 and 1,4. Many new reactions are coming soon. science.org/doi/10.1126/sc…

Our new study extending the transient directing group approach to unlock challenging γ-heteroarylation of ketones is online! Including new insight on how changing aldehyde to ketone switches TDG-induced regiocontrol in the palladabicyclic transition state. pubs.acs.org/doi/10.1021/ac…

It's been a long journey towards Himalensine A since I worked on this during my Masters in Dixon Group but the end result makes it even more gratifying. Huge congratulations to Sam, Roman, and the rest of the team for powering through this beautiful work! pubs.acs.org/doi/10.1021/ja…

Excited to have helped overcome long-standing issues of poor reactivity and substrate inhibition in unlocking the C-H functionalization of heteroarenes under Pd catalysis by designing a dual-catalyst system to tune Pd character. Congratulations to our team pubs.acs.org/doi/full/10.10…

With continuous molecular design of catalytic templates, we've now extended the power of precise structural editing and demonstrated regiocontrol in remote olefination of heterobiaryls. Excited to see this work published, congratulations to the entire team!onlinelibrary.wiley.com/doi/10.1002/an…

Our paper now in Journal of the American College of Surgeons (JACS) shows how ligand design enabled bromination of acids, featuring enzyme-inspired H-bonding mediated substrate anchoring via a proposed macrocyclic TS assembly. Congratulations to the entire Scripps team and all our collaborators! pubs.acs.org/doi/10.1021/ja…

Breath taking efforts from Pharma to find selective inhibitor for Sodium channels. Our CH editing of THF and THP scaffold in 2015 finds the the THF lead (vertex collaboration with Dean Stamos)optimized to give 30k fold selectivity. Medicine for acute pain, very much needed.

50 Shades of Oxidative Additions😈 Whether you like it salty, ligated, solvated, or just naked, palladium does the job. Learn more about the mechanisms of OA: a must-read for #chemistry students and anyone venturing into #catalyst design! ACS Catalysis pubs.acs.org/doi/abs/10.102…

Another big breakthrough in catalyst design by our group! Now employing Pd catalysis for aliphatic C-H diversification of alcohols for the first time. Congratulations to the entire team, excited for the upcoming discoveries.

We have now utilized the power of ligand control to achieve regioselectivity in β,γ-dehydrogenation of free carboxylic acids, providing a versatile platform for the downstream functionalization of complex molecules at remote γ-sites. pubs.acs.org/doi/10.1021/ja…

Since Enantioselective beta C-H activation in 2016, we have chased gamma and delta relentlessly, finally: science.org/doi/epdf/10.11…

Celebrating #HigherEducationDay! 🎓🌟 The Scripps Research Graduate Program is ranked among the nation's top 10 science graduate programs, according to U.S. News & World Report. Our commitment to research and innovation inspires the next generation of scientists. Read more: ow.ly/5eEH50SbisP

In our new report, we discovered a dual-ligand system to overcome the intrinsic electronic bias in the olefination of protected phenols without directing templates - our ligand design controlled site-selectivity by altering reversibility of C-H palladation.pubs.acs.org/doi/10.1021/ac…

Yamada-Koga asymmetric lithiation is part of the inspiration for our first project on asymmetric CH palladation in 2002. This recognition is so special to my coworkers: CH activation is finally a significant member of the asymmetric catalysis family, huge potential to yet improve

We broke 4 C-H bonds at once! This enantioselective cascade combines our earlier work on free acid dehydrogenation producing a norbornene equivalent in situ with Catellani-type polyarylation to construct 4 C-C bonds and 3 new stereosenters in a single step doi.org/10.1002/anie.2…

Honoured to receive the JM Award from IPMI! I'm most thankful to my doctoral advisor Prof. Jin-Quan Yu and to Scripps Research for the tremendous support and the unparalleled opportunities to advance the frontiers of catalysis and work with the most brilliant minds in the field.

Today marks a monumental milestone: 100 years of pioneering science at Scripps Research. 🎉 On December 11, 1924, philanthropist and journalist Ellen Browning Scripps laid the foundation for what would become a globally renowned institute. Learn more at 100.scripps.edu.

Our new breakthrough is out in nature! Our ligand design for a cationic catalyst assembly unlocked C–H coupling, arylation, and oxidation of ketones and esters. Congratulations to my collaborator Yi-Hao Li for driving this work with exemplary efficiency! nature.com/articles/s4158…

In the Yulab, Nik Chekshin discovered & developed novel catalytic systems for selective C-H functionalization, unlocking access to new chemical space & enabling synthesis of structurally diverse libraries of bioactive molecules & medicinal targets.💻: scripps.edu/graduation.

One of the most memorable moments of my PhD was the discovery of exceptional stereocontrol of MPASA ligands in asymmetric incorporation of nucleophiles into C(sp3)–H bonds. Excited to see first application published as the Editor's Choice Article J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…