🚀 LLMs can now do chemistry! Our new preprint shows that state-of-the-art reasoning models can now perform advanced chemical reasoning tasks, without any assistance from external tools. Here’s what o3-mini can already do👇 (1/🧵)

Greg Brockman NMR elucidation with o3 + RDKit is pretty cool.

Greg Brockman o3 can do full cheminformatics analysis from a single prompt. This is awesome!

AI companies have explicitly ignored chemical safety in their system cards.

MolSnapper: Conditioning Diffusion for Structure-Based Drug Design #DrugDesign pubs.acs.org/doi/10.1021/ac… Yael Ziv Fergus Imrie Brian Marsden Oxford Protein Informatics Group (OPIG) #JCIM Vol65 Issue9 #MachineLearning #DeepLearning

new paper from our work at Meta! **GPT-style language models memorize 3.6 bits per param** we compute capacity by measuring total bits memorized, using some theory from Shannon (1953) shockingly, the memorization-datasize curves look like this: ___________ / / (🧵)

🔥 Blog alert🔥 ChatGPT now has access to RDKit. Key highlights: 🧪 Molecule visualisation 📈 Multi-step cheminformatics analysis 🤔 ChatGPT doesn't feel "smarter" with RDKit access, but might be more useful for chemists. Read more: blopig.com/blog/2025/06/c…

Really pleased to share what I have been working on for 2 months: 🇬🇧 UK SovAI are today announcing our £8m seed investment into OpenBind - A consortium that will actually make AI for drug discovery great by generating 500k experiment protein-ligand complexes!! Explainer 🧵 (1/n)

AI could never replicate this

GPT-5 sets new SOTA on ChemIQ - our chemical reasoning benchmark. 🧪💥⚗️ The model scored 70.2%, with a 14% jump from the previous best model. A thread on the chemical intelligence of GPT-5 🧵 Sam Altman Greg Brockman (1/n)

AIR Street Capital's "State of AI" 2025 Report references Nicholas Runcie, Charlotte Deane, and Fergus Imrie's work on Assessing the Chemical Intelligence of Large Language Models. Read the whole report here: stateof.ai And preprint here: lnkd.in/gbuNXR93