I’m excited to share the most recent study from the mbruchas lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system! biorxiv.org/content/10.110…

Dr Paule V. Joseph Paule Joseph, PhD, MBA, CRNP, FAAN, NIAAA & NIDCD Intramural Researcher, was selected to be part of the Presidential Leadership Scholars, which brings together a diverse network of established leaders to collaborate & make a difference in the world. presidentialleadershipscholars.org/2025-class-of-…

Almost all neurons co-release peptides and small transmitters. Thrilled to share our latest research where new GRAB sensor promotes better understanding of the dynamics and molecular regulation between neuropeptide and neurotransmitter release in vivo. nature.com/articles/s4146…

Our paper on opioid receptor regulation of mPFC inhibitory microcircuits is out as an early release jneurosci.org/content/early/… Marie-Charlotte Max Joffe ! More to come on these systems in opioid dependence 🧠

🧠 🍄 ⚡️🐭 Now published in Nature Neuroscience … Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility nature.com/articles/s4159…

Nature Reviews Neuroscience Brain mechanisms underlying the inhibitory control of thought nature.com/articles/s4158…

Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons First preprint from the lab! Wonderful team effort, lead by incredibly talented Lee Vaasjo (Lee O Vaasjo, PhD) and Shawn Kotermanski biorxiv.org/content/10.110…

Thrilled to see this come to life and to have been part of the journey since the very beginning. Huge congratulations to Pablo and Gilles on building such a nice story! nature.com/articles/s4159…

Our Lab NIH sponsored work is out! cell.com/cell-reports/f… 🥳Vasopressin (AVP) excites BNST neurons via oxytocin receptor (not V1aR or V1bR) 🔬AVP excites CRF- and OTR-BNST neurons 🧠AVP inputs from SCN & SON excite BNST via OTR 🐁OTR-BNST neurons reduce anxiety in male rats

I am so proud of my partner Paule Joseph, PhD, MBA, CRNP, FAAN for being such an inspirational force for good and science. Congrats on your tenure!

A new study in mice uncovers a stress-sensing circuit that interacts with light to influence circadian outputs. The work offers a roadmap for exploring the circuits linking light, circadian/sleep, and stress-related psychiatric disorders. scim.ag/4kV9GcA

Unpacking the dynamic role of physical effort in shaping behavior Opinion by Boris Cheval (Boris Cheval 🇫🇷🇪🇸), Silvio Maltagliati (Silvio Maltagliati), Florent Desplanques (Florent Desplanques), & Wanja Wolff (Wanja Wolff) tinyurl.com/3rwkr9rx

:Trends in Cognitive Sciences The interoceptive origin of reinforcement learning cell.com/trends/cogniti…

Our new paper in collaboration with Bill Carlezon and Erik Musiek on the effects of pain on sleep architecture is now out at Neuropsychopharmacology . Work done by the amazing Dominika Burek and Nisa Ibrahim nature.com/articles/s4138…

GREAT NEWS! Our paper on dopamine signaling of valueless prediction errors is out in Science Advances! I found that striatal dopamine tracks cue-cue prediction errors in sensory preconditioning, which goes against model-free theories of dopamine function. science.org/doi/10.1126/sc…

This speaks to the importance of cross-species research that is constantly forward & back-translated between the clinic & lab. The importance of animal models leading to unanticipated discoveries - even in the realm of human psychology - is invaluable, especially in #psychiatry🧠

Excellent write-up on some of our recent findings. BBRFoundation Researchers Trace How Ketamine Acts on Specific Brain Circuits and Synapses to Relieve Anhedonia | Brain & Behavior Research Foundation bbrfoundation.org/content/resear…