Typically, men secrete testosterone (T) in a diurnal fashion, wherein it peaks in the morning and declines steadily across the day. Sleep, particularly REM sleep, is the major sleep stage that increases T.

Older males no longer show this robust rhythm:
pubmed.ncbi.nlm.nih.gov/6841562/#:~:te….

We think of beta-amyloid in Alzheimer’s disease as a toxic protein that we need to get rid of. However, anti-amyloid therapies don’t stop the continued progression of neurodegeneration. Why is this?

Do physiological levels of amyloid support neuronal processes? Seems like it…

Is amyloid beta a friend or foe? Claire Durrant (UK DRI at Edinburgh) discusses the protein's role in health and disease in this review in Nature Reviews Molecular Cell Biology

Read here ⬇️
buff.ly/3QoTmU7

Sleep’s First Half Crucial for Brain Reset

Researchers uncovered a vital function of sleep involving the weakening of synaptic connections formed during wakefulness, primarily occurring during the first half of the night.

Their study utilized zebrafish to demonstrate that this…

Found: the dial in the brain that controls the immune system nature.com/articles/d4158…

Very interesting! Can’t wait to read 😊

This is an oversimplification. Yes, sex can exert differences upon the brain, on average (in addition to socialisation and lots of other variables). There’s lots of variation both between and within each sex, in which the precise regions of the brain to display sex differences…

In these studies, are the changes in those brain regions directly related to sex-atypical characteristics, or are they just different from controls?

If body perceptual circuitry plays a role in gender dysphoria (GD)
development, wouldn’t general dysfunction in those circuits…

In these studies, are the changes in those brain regions directly related to sex-atypical characteristics, or are they just different from controls?

If body perceptual circuitry plays a role in gender dysphoria (GD)
development, wouldn’t general dysfunction in those circuits…

7 hours of sleep is associated with the lowest phenotypic age.

“In an interview in The Times of London, the psychologist Steve Stewart-Williams succinctly summarized the gender-equality paradox: ‘Treating men and women the same makes them different, and treating them differently makes them the same.’” bostonglobe.com/2024/04/25/opi…

Beauty of the circadian system. This transcription-translation feedback loop of reciprocal gene expression resides in every cell of your body (with a nucleus). This loop organizes all incoming signals in time and space to coordinate specific bodily functions in a temporal…

Females once again making males look simple 😂

Plants are now LGBTQIAP+ !?! 🙈

Adaptive immune changes associate with clinical progression of Alzheimer’s disease

…arneurodegeneration.biomedcentral.com/articles/10.11….

In a recent episode of Dr. Phil exploring the debate over youth transition, Leor Sapir explained one of the reasons why people believe the rate of transition regret is so low: detransitioners often don’t tell their doctors. “The system had completely forgotten about them.” 🧵

“Gender identity is at the very least a secondary sex characteristic”

Hmmmm 🤔 disagree…

Average neurological sex differences ≠ evidence for “gender identity”, nor do differences in the brains of transgender individuals.

No neuroscience currently supports the concept of an innate “gender identity”.

Correlation is NOT causation.