I use the CRISPR/Cas gene editing technology in my research to knockout genes for different purposes, i.e. loss of function studies. How do you use CRISPR? #SciCommUU19

One of the ways to combat rejection after transplantation for cell replacement therapies can be to knockout B2M and insert HLA-E as a transgene, as Gornalusse et al. demonstrated in their article! tinyurl.com/y4oekuqr

Another interesting approach to reducing rejection is presented by Xu et al. that use CRISPR to remove not all HLA-I molecules but only HLA-A and B, leaving HLA-C intact. tinyurl.com/y2pujkop

Do you want to know more about how I and others at KI use CRISPR in our research? Sign up for the CRISPR mini-symposium in Biomedicum next Friday! forms.gle/8ipotTA3ZhifRe…

What do you think is the more sustainable solution to combating transplantation rejection? Next week at #SciCommUU19 I hope to present our strategy to you! See you then!

Take a look at what we are currently working on at the Lanner lab Karolinska Institutet! #stemcell #embryo #regenerativemedicine

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”