COPD Cell Atlas is finally out! Read “Characterization of the #COPD alveolar niche using single-cell RNA sequencing” for many exciting & novel insights! Kudos Maor Sauler John McDonough Ivan Rosas, Pascal N. Timshel all others, for this amazing effort. See 🧵below nature.com/articles/s4146…

Finally out! Comprehensive visualization of cell-cell interactions in single-cell and spatial transcriptomics with NICHES. Kudos Drs Raredon, Niklason and Kluger! See paper here academic.oup.com/bioinformatics… and gorgeous thread 👇🏼

Very happy to share our preprint on pooled base editing in primary human T cells to discover genetic variants modulating T cell function. Incredible effort by MD/PhD student Zach Walsh and other members of the bizarMD lab at Columbia University.

Excited to share our new preprint! We developed methods for - and executed - pooled base editor screens of >100 critical T cell signaling genes in primary human T cells. We leveraged our findings to characterize critical protein domains and engineer superior anti-tumor T cells!

SO excited to see this work led by Zach Walsh and Parin and co-supervised by Johannes Melms and bizarMD finally out in the world. Science beautifully summarized below ⬇️, but I wanted to talk a little more about the secret sauce behind the paper and hand out 💐 #AcademicChatter

Excited to share our work on base editing in primary human T cells! Very grateful to be working with this incredible team!

Very excited to share new work from the lab dissecting mechanisms of liver-metastatic organotropism in melanoma and other cancers. Huge congrats to fearless post-doc Meri Rogava (on the job market!) who led this multi-year study! Below a brief summary... nature.com/articles/s4301…

Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens go.nature.com/3yxjW7q

Congratulations to Lindsay Caprio somnath tagore, many people in my group, and outstanding collaborators Denis Kresimir Bestak Fei Chen Lab Caris Life Sciences and many others on this paper, profiling non-small cell lung cancer brain metastases nature.com/articles/s4159…

Excited to share a new paper: tinyurl.com/49u5e6by Cell: a framework to accelerate variant classification, diagnosis & treatment of immune disorders & genetic disorders more broadly. Led by superstar, juggernaut & future dermatologist Zach Walsh

Thrilled to share the latest work from my PhD in the bizarMD group! This has been a dream MD/PhD project, culminating in data that has already enabled access to precision therapy for a patient. Tweetorial below:

1/ I’m excited to share recent work on inferring cell-cell interactions using attention by Justin Hong (@justjhong.bsky.social) and me, supervised by Elham Azizi. Open the thread 🧵for a brief tweetorial of our method. bioRxiv link: biorxiv.org/content/10.110…

Congrats to BVH 2018 grad Gabriel J. Gress & BVW 2018 grad Neeharika Kothapalli - the only 2 KS students named 2018 U.S. Presidential Scholars. This is one of the most prestigious national awards bestowed upon a graduating senior. Way to go! #BVProud district.bluevalleyk12.org/DistrictInform…