💫NEW: Tamra Werbowetski-Ogilvie, Taylor, Jamie Zagozewski, Olivier Saulnier & co report a noncanonical role for OTX2 in regulating #AlternativeSplicing and controlling a stem cell and pro-tumorigenic splicing program in group 3 #medulloblastoma. nature.com/articles/s4155…

💫NEW: Duan & co identify a CD8+ #Tcell population that migrate from bone marrow to the small intestine during leukemogenesis and then traffic back to contribute to anti-#leukemia immune responses during #chemotherapy treatment. 👉🏻rdcu.be/dQ0wY nature.com/articles/s4155…

📑: Julia Magdalena Majewska Amit Agrawal et al fr/Valery Krizhanovsky show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1, by downregulating its proteasomal degradation to accumulate in ageing and chronic inflammation. nature.com/articles/s4155…

💫NEW: Lv, Wang, Lin, Ye et al. report that mTORC2 phosphorylates #cGAS to promote its chromatin localization and SWI/SNF recruitment to regulate target gene expression, thereby mediating plasticity and #chemoresistance in #ColorectalCancer. nature.com/articles/s4155…

💫NEW: Liang, Yan, Long, Ji et al. find that the origin and dynamics of 5-hydroxymethylcytosine (5hmC) during early development are not conserved between humans and mice and that 5hmC contributes to the activation of human #embryonic genes. nature.com/articles/s4155…

💫NEW: Sefi Rosenbluh & co use large-scale loss-of-function RNA-interference screens to identify circular RNAs that are direct regulators of important signalling pathways and also common essential and tissue-specific #circRNAs. 👉🏽rdcu.be/dRrO7 nature.com/articles/s4155…

🥂Congratulations to Jay Shendure, wei yang, Nobu Hamazaki & co for their new Open Access study in our journal (Nature Cell Biology): an early pulse of retinoic acid induces human #gastruloids with a #NeuralTube, segmented somites and more advanced cell types. nature.com/articles/s4155…

📢 Review article Nature Cell Biology :"#Gasdermins as evolutionarily conserved executors of #inflammation and #celldeath" by Kaiwen Chen & Broz Lab nature.com/articles/s4155…

A first step towards a basis for research on #StemCell based #EmbryoModels rdcu.be/dSHtz Nature Cell Biology We hope that this will be useful in this new field where quality control and appropriate criteria are needed

💫NEW: Julia Magdalena Majewska Amit Agrawal Valery Krizhanovsky & co show that #p16-expressing #senescent cells enhance PD-L1 stability by downregulating its proteasome-mediated degradation, leading to their accumulation in aging and chronic inflammation. nature.com/articles/s4155…

💫NEW: Experimental evolution & #chromosome engineering probe the link between #karyotype changes and #CellDivision machinery and show that spindle organization dictates the available trajectories for karyotype evolution. Jana Helsen Gavin Sherlock Gautam Dey nature.com/articles/s4155…

💫NEW: Bill Dauer, Sam Pappas, Barmada Lab, Sumin Kim, UTSW O'Donnell Brain Institute & co show that Torsin A is required for the maturation and normal localization of nascent #neuronal #NuclearPoreComplex. 👉🏿rdcu.be/dSPKD nature.com/articles/s4155…

The rapid progress in the #EmbryoModels field has necessitated the establishment of efficiency and fidelity criteria. I am therefore super excited about this very important piece we have published in our journal (Nature Cell Biology): rdcu.be/dTbLD nature.com/articles/s4155…

💫NEW: Stankunas and Köhler define how the nucleoplasmic portion of the #NuclearPoreComplex (NPC), the basket, docks onto the #NPC core. Max Perutz Labs Vienna #nuclearpore #nuclearbasket #Nup60 #Mlp1 nature.com/articles/s4155…