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The April issue is live, with a focus on cancer immunotherapy nature.com/nbt/volumes/43… On the cover, recent clinical trials and patient reports have found promising outcomes of locoregional administration of CAR T cells across different solid tumors go.nature.com/3Z4eBiQ

Spotlight on cancer immunotherapies go.nature.com/3XUTPkM

Excited to share our review on CAR arming of the innate immune cells. Engineering innate immune cells for cancer immunotherapy | Nature Biotechnology nature.com/articles/s4158…

Engineering innate immune cells for cancer immunotherapy go.nature.com/3E9NbjZ

A shifting market environment and strategies fueling innovation in prostate cancer treatment go.nature.com/43ZRl8B

In Brief: U.S. FDA approves the first RNAi drug for treating heart failure caused by amyloidosis. Alnylam Pharmaceuticals gets the nod for #Amvuttra to treat transthyretin amyloid cardiomyopathy caused by sporadic or hereditary ATTR nature.com/articles/s4158… rdcu.be/ehRIa

A small microbial peptide that stabilizes the immune protein MYC2 makes citrus trees more resistant to a devastating plant disease called Huanglongbing science.org/doi/10.1126/sc… #NBTHighlight

Virtual cells for predictive immunotherapy go.nature.com/4jfqM3Y

Prime editing in hematopoietic cells is improved by engineering nucleotide metabolism go.nature.com/3X2vUjx rdcu.be/eh3ak

A hollow fiber bioreactor with improved spatial distribution of semipermeable hollow fibers is used to produce a nugget-sized piece of chicken meat cell.com/trends/biotech… #NBTHighlight

A tool to dissect regulatory DNA in its endogenous context enables the identification of designed small edits (<10 bp) that fine-tune gene expression, with potential therapeutic implications.  cell.com/cell/fulltext/… #NBThighlight

Making cell therapy accessible: challenges and opportunities go.nature.com/3YCJn1o

Not just obesity: GLP-1 receptor agonists advance on addiction nature.com/articles/s4158…

Five questions with Jie Sun go.nature.com/3RSlwqL

Using G•U wobble base pairs at specific loci increases RNA base-editing precision and efficiency go.nature.com/3zBhiOl rdcu.be/eh3aC

Turn cold tumors hot by reprogramming the tumor microenvironment go.nature.com/42Bo9lT

Mismatch repair inhibitors lift off in Huntington’s nature.com/articles/s4158…