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The April issue is live, with a focus on cancer immunotherapy nature.com/nbt/volumes/43… On the cover, recent clinical trials and patient reports have found promising outcomes of locoregional administration of CAR T cells across different solid tumors go.nature.com/3Z4eBiQ

Spotlight on cancer immunotherapies go.nature.com/3XUTPkM

Excited to share our review on CAR arming of the innate immune cells. Engineering innate immune cells for cancer immunotherapy | Nature Biotechnology nature.com/articles/s4158…

Engineering innate immune cells for cancer immunotherapy go.nature.com/3E9NbjZ

A shifting market environment and strategies fueling innovation in prostate cancer treatment go.nature.com/43ZRl8B

In Brief: U.S. FDA approves the first RNAi drug for treating heart failure caused by amyloidosis. Alnylam Pharmaceuticals gets the nod for #Amvuttra to treat transthyretin amyloid cardiomyopathy caused by sporadic or hereditary ATTR nature.com/articles/s4158… rdcu.be/ehRIa

Cell therapies are transforming our ability to treat cancer but are out of reach for many patients. Nature Biotechnology asked experts to share their insights into pressing challenges and promising strategies to make these therapies more broadly accessible nature.com/articles/s4158…

A small microbial peptide that stabilizes the immune protein MYC2 makes citrus trees more resistant to a devastating plant disease called Huanglongbing science.org/doi/10.1126/sc… #NBTHighlight

Virtual cells for predictive immunotherapy go.nature.com/4jfqM3Y

Prime editing in hematopoietic cells is improved by engineering nucleotide metabolism go.nature.com/3X2vUjx rdcu.be/eh3ak

A hollow fiber bioreactor with improved spatial distribution of semipermeable hollow fibers is used to produce a nugget-sized piece of chicken meat cell.com/trends/biotech… #NBTHighlight

A tool to dissect regulatory DNA in its endogenous context enables the identification of designed small edits (<10 bp) that fine-tune gene expression, with potential therapeutic implications.  cell.com/cell/fulltext/… #NBThighlight

The development of therapeutic cancer vaccines is seeing exciting progress recently. Curious how researchers are dealing with challenges to translate new technologies to the clinic? Nature Biotechnology asked experts for an update. nature.com/articles/s4158…

Making cell therapy accessible: challenges and opportunities go.nature.com/3YCJn1o

Not just obesity: GLP-1 receptor agonists advance on addiction nature.com/articles/s4158…

Five questions with Jie Sun go.nature.com/3RSlwqL

Using G•U wobble base pairs at specific loci increases RNA base-editing precision and efficiency go.nature.com/3zBhiOl rdcu.be/eh3aC

Turn cold tumors hot by reprogramming the tumor microenvironment go.nature.com/42Bo9lT

Mismatch repair inhibitors lift off in Huntington’s nature.com/articles/s4158…