SCSS Symposium 2022: Registration is open - mailchi.mp/d04991d7e09c/s…

A self-sustaining molecular loop that drives Parkinson’s disease can be targeted in mice, new research answers a longstanding question about Wnt signaling, and more in this week’s new issue of Science Signaling. fcld.ly/q53lnia

#Parkinsonsdisease #Parkinsons #neuroimaging #stemcells

#AlzheimersDisease #ipsc #biomaterials #stemcells

We found that blood miR-150-5p was upregulated in #AlzheimersDisease #Dementia which could be a promising cost-effective and non-invasive biomarker for AD. Read our article published in Journal of Alzheimer's Disease! pubmed.ncbi.nlm.nih.gov/35811521/

An experimental treatment for Alzheimer’s disease can break a molecular loop and protect neurons in mouse models of #ParkinsonsDisease, suggesting similar approaches could prove beneficial for this incurable neurodegenerative condition. fcld.ly/j7bul55 @SciSignal

New paper from the Neural Stem Cell Research Lab! They found that in cultured neurons & brain tissue from mouse models of #ParkinsonsDisease, LRRK2-mediated phosphorylation of APP increased the abundance and activity of the APP intracellular domain. 🧠 Science Signaling bit.ly/3PGudRC

A positive feedback loop between AICD and #LRRK2 drives #neurodegeneration and mitochondrial dysfunction in #ParkinsonsDisease but can be targeted with the experimental drug itanapraced, show experiments in mice from the Tan and Zeng labs. Singapore General Hospital (SGH) Neural Stem Cell Research Lab fcld.ly/ccrcssg

Annovis Bio Annovis Bio has announced that the 1st patient in the Phase 3 clinical trial evaluating buntanetap (aka ANVS401, Posiphen) in early stage #Parkinsons has been dosed; The trial will enroll a total of 450 participants, treatment for 6 months irpages2.eqs.com/websites/annov…

An experimental therapy for Alzheimer’s disease can break a molecular loop and protect neurons in mouse models of Parkinson’s disease, hinting similar approaches could prove beneficial for this incurable neurodegenerative condition. Neural Stem Cell Research Lab #Neuroscience fcld.ly/2ro163e

Thanks for the feature! Ingentium Parkinson's Disease The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson's disease. magazine.ingentium.com/2022/08/24/the…

Upcoming exciting ⁦Society of Developmental Biologists Singapore⁩ seminar by Anna Akhmanova on #microtubules! ⁦Philip Ingham⁩ ⁦Antonia Monteiro⁩ ⁦On Sun Lau⁩ ⁦Neural Stem Cell Research Lab⁩ Hongyan Wang⁩ ⁦Yusuke Toyama⁩ ⁦Reversade Lab⁩

Upcoming ⁦ Society of Developmental Biologists Singapore virtual ⁩seminar by Associate Professor Quenten Schwarz on interneuron development, happening on 27 October! ⁦ Philip Ingham Antonia Monteiro On Sun Lau Neural Stem Cell Research Lab Hongyan Wang Yusuke Toyama Reversade Lab UniSA Research

Check out our latest study on the effects of itanapraced on #Parkinsons disease! Thanks Medical News Today for the feature 👍🏼

Our lab is at the #ADPD2023!! First physical international conference in 3 years! AD/PD - Advances in Science & Therapy