Read this #preprint on Research Square: Archaic chaperone-usher pilus self-secretes into a superelastic zigzag spring architecture researchsquare.com/article/rs-936… 2/2

We solved the cryoEM structure of hair-like surface organelles that enable multidrug-resistant bacteria to form biofilms. The study suggested a new approach to treat a wide range of bacterial infections. The paper is under review now and available here: researchsquare.com/article/rs-936…

Activated β-arrestin 1 not only scaffolds but also allosterically activates its downstream partners: now shown for C-Raf jbc.org/article/S0021-…

Light 'em up: efficient screening of gold grids in cryo-EM biorxiv.org/cgi/content/sh…

Cryo-EM structure of a type IV secretion system nature.com/articles/s4158…

Our paper on the biofilm-forming pili of Acinetobacter baumannii is published in nature ! Can't describe how very happy I am :) #cryoEM, #biofilms, #pili Archaic chaperone-usher pili self-secrete into superelastic zigzag springs disq.us/t/49a4s2u

Today in partnership with EMBL-EBI, we’re releasing predicted structures for nearly all catalogued proteins known to science, which will expand the #AlphaFold database by over 200x - from nearly 1 million to 200+ million structures: dpmd.ai/AF-22-TW 1/

Feel proud to be featured by Steffanie Strathdee, PhD 🗡️ 🦠Superbug Slayer🗡️ on our latest paper on #superbugs!

Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps biorxiv.org/cgi/content/sh…

On the reading list!

Peter Shen Peter Shen took us through his #cryoEM sample prep journeys with endogenous protein complexes & how cryoem101.org helps share this knowledge in our CryoEM Current Practices webinar series. The talk will be posted soon at youtube.com/c/CryoEMServic… cryoemcenters.org

A universal coupling mechanism of respiratory complex I nature.com/articles/s4158…

Microsecond melting and revitrification of cryo samples with a correlative light-electron microscopy approach biorxiv.org/cgi/content/sh…

An iterative approach for improving #AlphaFold protein model quality using experimental density maps, where rebuilt models are used as templates in new AlphaFold predictions, from @TerwillTom and colleagues. OA paper: nature.com/articles/s4159…

Polyelectrolyte coating of cryo-EM grids improves lateral distribution and prevents aggregation of macromolecules scripts.iucr.org/cgi-bin/paper?…

Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy biorxiv.org/cgi/content/sh… #biorxiv_biochem

Check out our work on how beta-arrestin activates proto-oncogene kinase Src! This is the first structure of beta-arrestin in complex with the effector enzyme biorxiv.org/content/10.110…

Check out our work on the discovery of small molecule modulators of beta-arrestins! biorxiv.org/content/10.110…