Drs. Christopher J. Yarnell & Michael Fralick review the article by Desai et al. describing methods for individualized treatment effect prediction models using TOPCAT data, calling it an informative example of exploring heterogeneity of treatment effects. eviden.cc/3TuT2DP

Transcatheter aortic-valve implantation is increasingly used instead of surgical valve replacement, but evidence comparing the two approaches in clinical practice is limited. Research findings are summarized in a new Quick Take video. youtu.be/9UHIfXjMFhQ

Joshua M. Sharfstein, M.D., discusses a shift by the Supreme Court that is limiting the ability of states, Congress, and federal agencies to protect public health. Listen to the full interview: nej.md/3UQrRVV

A 72-year-old man who had emigrated from Zimbabwe 20 years previously presented with a 17-year history of swelling of the penis, scrotum, and left leg. Read the full clinical case from University of Basel: nej.md/3JK9VWF

Recent approvals of exa-cel for treatment of sickle cell disease and transfusion-dependent thalassemia mark the dawn of the era of gene editing in medicine. But ensuring access will be challenging. Full Perspective: nej.md/4d9XbGt

#Hematology

CORE IM Read the MANDALA trial results published in NEJM: nej.md/3Me7344 3/3

CORE IM Listen to the full episode, which puts research into context by illustrating how clinicians arrived at the current standard of care, and interpreting what the findings of this trial may mean for patients: nej.md/3UdZf8P 2/3

While discussing the results of the MANDALA trial, the hosts of Beyond Journal Club, a podcast by CORE IM in collaboration with NEJM Group, address why albuterol alone is no longer the recommended first-line rescue medication for adult patients with asthma. 1/3

“In a randomized, placebo-controlled trial in adults with obesity, intranasal oxytocin administered four times daily for 8 weeks did not reduce body weight.” Read the full trial results: eviden.cc/3UvTFz2

#Endocrinology

Original Article: Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size (LASTE) nej.md/4dwLPfW

#EmergencyMedicine

Medicine and Society: Global Health Law for a Safer and Fairer World nej.md/4b8k6R9

#PublicHealth

Measles Is Making an Unwelcome Comeback

With the rising number of U.S. #measles cases, elimination status is threatened. jwat.ch/3wmsXQ3

#IDTwitter

A chest radiograph and computed tomographic scan of the chest showed the tip of the right ventricular lead in the left pleural space. What rhythm does the electrocardiogram show? nej.md/IC05092024 2/2

A 96-year-old woman presented to the emergency department with a 1-day history of pleuritic chest pain 4 days after a single-chamber transvenous pacemaker had been implanted. 1/2

The U.S. FDA is considering implementing a nicotine product standard, under which cigarettes could contain only very low levels of nicotine. Preparing for the tobacco industry’s potential response is important. Read the full Perspective: nej.md/3UqLQZT

In the latest Case Record of the MGH, a 30-year-old woman was evaluated because of back pain, leg stiffness, and falling. Tone was increased in the legs. Exaggeration of the normal lumbar lordosis was seen on MRI. A diagnosis was made. Read the full case: nej.md/4bkxuS0

Automated surveillance for outbreaks using microbiology data and a space-time scan statistic to alert personnel to an outbreak in progress did not significantly reduce the overall size or duration of outbreaks in this large cluster-randomized trial. 1/2

Correspondence: Specificity of CRISPR-Cas9 Editing in Exagamglogene Autotemcel nej.md/3w9KR8p