Original Article: “Intranasal Oxytocin for Obesity” by Elizabeth A. Lawson, MD, MMSc, et al. eviden.cc/3UvTFz2

#Endocrinology #ClinicalTrials

The antibody that mediates the occurrence of VITT associated with adenoviral-based Covid-19 vaccines is nearly identical to the antibodies produced in response to natural adenoviral infection. Read the full correspondence: nej.md/3ygUva1

This feature about an attending preparing for her week of service offers a case vignette accompanied by two essays, one supporting visiting patients early in the morning, before rounds, and the other recommending no prerounding. Read the case and vote: nej.md/3ysPpY9

In the latest Case Record of the MGH, a 73-year-old woman was transferred to the hospital because of rash, leukocytosis, and eosinophilia. CT revealed a mass in the lung and diffuse lymphadenopathy. A diagnosis was made. Read the full case: nej.md/3QM4fzD

A 66-year-old man with recently diagnosed cirrhosis associated with metabolic dysfunction–associated steatohepatitis presented with a 1-day history of melena and hematemesis. Read the full clinical case from @kpmedschool and Thrive with KP: nej.md/3JZTshp

Protecting health is a team sport — yet the public health and clinical care systems meant to advance this goal have been siloed for too long. Read the full Perspective: nej.md/4cOLRPQ

Olezarsen in Hypertriglyceridemia with High CV Risk

Olezarsen for Familial Chylomicronemia Syndrome

For these articles and more, browse the full issue: nej.md/current-issue

Original Articles in the May 16/23, 2024, issue of NEJM:

Andexanet for Factor Xa Inhibitor–Associated Hemorrhage

Perioperative Nivolumab in Resectable Lung Cancer

A machine learning intervention for serious illness conversations saved over $13 million for patients with cancer by reducing end-of-life therapy and outpatient costs. Read the full study results by Tej A. Patel et al.: nejm.ai/4aq6oIb

For congenital thrombotic thrombocytopenic purpura, recombinant ADAMTS13 shows promise both as an on-demand and a prophylaxis regimen. jwat.ch/3ylU2Dp

NEJM #hematology

Familial chylomicronemia syndrome, an inherited form of severe hypertriglyceridemia, does not respond well to conventional lipid-lowering drugs. Research findings on olezarsen, an investigational antisense therapy, are summarized in a new Quick Take video. nej.md/4bnDuJT

From the NEJM Archive: A Functional Relation of the Tonsil to the Teeth (Original Article, May 20, 1909) nej.md/3UKRHcP

Fundamentals of Medical Ethics: Keep Your Eyes on the Prize — Focusing on Health Care Equity by Alicia Fernandez & Marshall H. Chin, M.D. nej.md/3wwQYnx

'... automated systems such as WHONET-SaTScan warrant further investigation to support infection prevention efforts and improve patients’ safety.' Learn more in the editorial by Scott Roberts and Richard A. Martinello, MD: eviden.cc/3xPvJh1

Heat waves are increasing in frequency, duration, and intensity and are already a substantial threat to human health.

Read more in 'Climate Change, Extreme Heat, and Health,' the latest review in the Fossil-Fuel Pollution and Climate Change series: nej.md/3UZdSgH

Earn CME through this free webinar and gain a comprehensive understanding of recent advancements in the management of obesity with a focus on pharmacotherapies.

Learn more and reserve your spot: nej.md/3UsdqpA

Perspective: Underestimated Challenges for Social Care Initiatives — Regulatory Compliance nej.md/3UT1sqC

#HealthPolicy

The second episode of the four-part Double Take video miniseries on depression delivers a primer on first- and second-line treatments for depression. 🎥 Watch the full video: nej.md/3V7jjud

Original Article: Dupilumab for COPD with Blood Eosinophil Evidence of Type 2 Inflammation (NOTUS) nej.md/4dF7N06

#ATS2024 American Thoracic Society (ATS)

Original Article: “CDK4/6 Inhibitor Efficacy in ESR1-Mutant Metastatic Breast Cancer” by Dr. Maxwell Lloyd et al.: eviden.cc/3U5CDpX

#Oncology #CancerResearch