Looking forward to speaking 23andMe

Why it is so hard to predict complex diseases and traits from DNA? Here is a collection of my go-to slides, a short story about the predictive ability of polygenic risk scores (PRS).

Healthcare consumerization is forging a new model of genetic testing businessinsider.com/new-model-gene… via Business Insider

Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank bmj.com/content/365/bm…

Thank to Brian Jetter for sharing this incredible story. Genomics saving lives ✊ washingtonpost.com/national/healt…

How Should Patients and Providers Interpret the US Food and Drug Administration’s Regulatory Language for Direct-to-Consumer Genetic Tests? | Journal of Clinical Oncology ascopubs.org/doi/full/10.12…

samharris.org/podcasts/162-m…

Interesting new partnership between Kroger and Myriad Genetics businessinsider.com/kroger-brings-… via Business Insider

"We show that polygenic risk scores have substantial potential for risk stratification for relatively common cancers such as breast, prostate and colon." biorxiv.org/content/10.110… Analysis of common genomic variants for 14 types of #cancer, by Yan Zhang Johns Hopkins Bloomberg School of Public Health et al

Johns Hopkins Bloomberg School of Public Health Impressive paper on genomics of common medical conditions: "For most complex traits, the genes & loci with the most critical biological effects often differ from those with the strongest common-variant associations" cell.com/ajhg/fulltext/… AJHG by Luke O'Connor & colleagues

#AI identifies genes linked to heart failure eurekalert.org/e/9h45 ahajournals.org/doi/10.1161/CI… "The genetic risk scores established from this study could be tested in future studies to create an integrated and personalised risk assessment tool for heart failure."

Yesterday was #WorldHeartDay so it’s just as good a time as any to find out your genetic risk for heart disease using the MyGeneRank app #heartdisease #genetictesting #polygenicriskscore

Android version now available! play.google.com/store/apps/det…

New updates to the app brings the following to Android and iOS: - Updated polygenic risk score - Improved UI / UX - Spanish language option - Added option for genetic counseling

Nice highlight of our MyGeneRank collaboration with @myDNAfeed to bring genetic counseling to polygenic risk prediction. This is the model to scale reactive genetic testing to proactive population screening. genomeweb.com/informatics/dn…

It's not just the loss of lives. It's the average 10-11 years that each of those dying have lost. "The study shows ... people killed by #COVID19 had only slightly higher rates of underlying illness than everyone else their age." economist.com/graphic-detail… The Economist Data Team

MyGeneRank servers are currently down as we are implementing some new security updates. Will be back online shortly.

On the day that the United States reached the 100,000 death toll by CSSE at JHU: All in < 90 days. (February 28th was the 1st) The country stands alone in the world —not just on this graph of loss of American lives—but also as the only country with no plan.

Many assume all patients with high-risk DNA mutations — such as familial hyperchol mutations for heart attack — will develop disease But some remain healthy ‘Polygenic background’ one important reason why Press release: bit.ly/2EkAqDI Paper: go.nature.com/3hePocV

DEADLY CAR WASH ACCIDENT: Officers found the man stuck between equipment and his car, police said. trib.al/yiYZFP6