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A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization dlvr.it/TLDyVX

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability dlvr.it/TLFcFT

Emerging mechanisms underlying formaldehyde toxicity and response dlvr.it/TLFjKQ

No (innate immune) training without lactate dlvr.it/TLFnlX

Finding a foothold to fight: New insights into the viral RNA sensing and activation mechanism of OAS2 dlvr.it/TLFwLv

Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma dlvr.it/TLG1fv

Online Now: Synaptic activity causes minute-scale changes in BAF complex composition and function dlvr.it/TLG9Kv

Online Now: Chip (Ldb1) is a putative cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation dlvr.it/TLGfl0

Online Now: Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells dlvr.it/TLGsVq

Online Now: Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain dlvr.it/TLH0dP

Online Now: Mitochondrial fumarate inhibits Parkin-mediated mitophagy dlvr.it/TLHzKx

Online Now: The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress dlvr.it/TLJ7D5

Online Now: SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging dlvr.it/TLK4Lx

Online Now: The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible dlvr.it/TLKCPC

We are excited to see our postdoc Khoa Tran paper out today in Molecular Cell! He finds that SIRT7 regulates NUCKS1 chromatin binding during senescence and aging! cell.com/molecular-cell…

Online Now: Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma dlvr.it/TLKJXg

Online Now: CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance dlvr.it/TLL8bV

Very honoured to have contributed to this cool work from our lab (at Gurdon Institute), led by the wonderful Rachael Matthews ☺️ now out in Molecular Cell CRAMP1 drives linker histone expression to enable Polycomb repression cell.com/molecular-cell…

Online Now: CRAMP1 drives linker histone expression to enable Polycomb repression dlvr.it/TLLHwL

Online Now: Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation dlvr.it/TLNZlT