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Great to have contributed to this paper on using #CRISPR base editing to boost fetal hemoglobin to treat #SickleCellDisease led by Dr Mohankumar in India and now published in eLife - the journal - CRISPR base editors are already the next big thing - thanks David R. Liu doi.org/10.7554/eLife.…

We’re delighted to introduce the 10 winners and two runners-up of this year’s Ben Barres Spotlight Awards! 🎉 And this year, five of the 12 recipients are authors of Reviewed Preprints. Learn about them and the work they’re doing in the thread below ⬇️ elifesciences.org/inside-elife/6…

Kumarasamypet Mohankumar (Mohankumar K. Murugesan) aims to develop genome-editing strategies to treat genetic blood disorders. He says the award will “help us extend our published preclinical work to in vivo models and, in turn, evaluate its potential clinical applications”.

Thanks to eLife Community for this award. It would not be possible without the support from Centre for Stem Cell Research _ CMC _ inStem iBRIC-inStem Department of Biotechnology

Happy to share the work from our lab done by @anilageorge10 on the correction of the sickle mutation using prime editor Centre for Stem Cell Research _ CMC _ inStem iBRIC-inStem Department of Biotechnology HRDGCSIR #CRISPR #sicklecelldisease #PrimeEditing #GenomeEditing frontiersin.org/articles/10.33…

Pleased to share our work on the use of nickase-deficient base editors to avoid large deletions while editing the highly homologous regions such as the therapeutically relevant HBG promoters biorxiv.org/content/10.110… #baseediting #sicklecellanemia #CRISPR #genomeediting

Excited to share our latest research work published on Molecular therapy. We performed a structural/function analysis of the BCL11A-XL specific ZnF domains unraveling exciting functions of the C-terminal ZnF domains of the longer isoform doi.org/10.1016/j.ymth…

Congratulations VIGNESH RAJENDIRAN NIVEDHITHA Devaraj and the rest of the team. Thanks Merlin Crossley Jacob Corn Joel Mackay Stacia Wyman (she/her) Srujan Marepally and others. Molecular Therapy CRISPRpapers Department of Biotechnology Centre for Stem Cell Research _ CMC _ inStem iBRIC-inStem #BCL11A #ZnFdomains #baseediting

Congratulations Kirti Prasad and the rest of the team. Thanks Gregory Newby Shaji R Velayudhan Srujan Marepally Saravanabhavan Thangavel and others. Molecular Therapy Family of Journals CRISPRpapers Centre for Stem Cell Research _ CMC _ inStem iBRIC-inStem SERB Department of Biotechnology #baseediting #CRISPR #Thalassemia #hematology

Delighted to share our lab's latest paper published in Molecular Therapy Nucleic Acids on correction of various β-thalassemia mutations in coding and non-coding regions using base editors” DOI: doi.org/10.1016/j.omtn…

Excited to share our publication highlighting the use of nickase-deficient base editors to overcome interstitial deletions in homologous regions cell.com/molecular-ther… Thanks to everyone involved! Centre for Stem Cell Research _ CMC _ inStem iBRIC-inStem Department of Biotechnology #baseediting #CRISPR