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Confused by all the "what is epigenetics" discourse? Well I have just the thing for you -- presenting the Epigenetics Alignment Chart!

If you agree that ERC should remove their academic age limits on ERC grants - please Sign this Petition! Please also RT: #EDI #science #EuropeanScience #ERCgrant chng.it/zvm4fDmFdj via Change.org UK

The age limit makes no sense.

VACANCY - We're looking for a Postdoctoral Researcher in to join the Tung Le Group at the John Innes Centre, working on cutting-edge science in Molecular Microbiology. okt.to/bHDZ4M Closing date - 26th February 2023 Contract - 3 Years, full time Norwich Research Park

RNA Chemistry meets Plant Biology. Please check out our review of RNA in Plants. Collaboration between the #Assmann and #Bevilacqua labs. academic.oup.com/plcell/advance…

Biophysics question: In transcription, RNApol generates positive supercoils ahead of it and negative ones behind it WHY? Why doesn’t RNApol instead simply track 1 strand of the duplex, follow its helical twist along the duplex, and thus rotate without any supercoil generation?

Got to read this fast because it will be outdated very soon! The field is moving fast.

One molecule at a time, we made our way from diffusing cohesin on DNA and CTCF, to loop-extruding one. While the CTCF N-terminus is consistently more successful in prohibiting cohesin bypass for diffusing and extruding complexes, ...

Furthermore, the interaction can be pretty short-lived. A cohesin can be blocked by CTCF, let partially go of the loop, then try, again, etc. The system is very dynamic! If a cohesin loses parts of the loop and continue extruding away from the CTCF is also tension-controlled.

Extremely excited to preprint this fascinating story. Spearheaded by super-talented postdoc Hui Li Hui Li we found how virulence function diversity may be achieved in an effector repertoire! The Sainsbury Laboratory #mpmi #effectorsrock x.com/biorxiv_plants…

Pathogens are notorious for producing diverse effector proteins that manipulate host cellular processes. But how is functional diversity generated in an effector repertoire? Thrilled to share our fascinating story. biorxiv.org/cgi/content/sh…… #biorxiv_plants

We've developed a method to site-specifically introduce chemical modifications *anywhere* on a plasmid 💪 We used this to generate light-activated plasmids 🔦🧬🧪🧫! Preprint led by Khoa Chung Oxford Chemistry UCL Chemistry SynBio CDT tinyurl.com/5fdevtjc

NEWS - Professor Dame Caroline Dean awarded Mendel Medal Professor Dame Caroline Dean has been named by The Genetics Society as the recipient of the #Mendel Medal for 2023 okt.to/nBKP6G Norwich Research Park

It is a general truth that complex feedback regulations exist in biological systems, in order to achieve the flexibility of the system in response to environmental stimuli while ensuring stability within the system. This logic is different from the simple linear logic.

In particular, the complex feedback conditions between the non-coding transcription and chromatin regulations. Using linear logic to understand the biological system is like the story where a blind man tried to understand what the elephant looks like by touching it.

With elegant experiment designs and analysis, this article showed how plant systems are using parallel input signals and sophisticated feedback to ensure that plants correctly recognize the cold “winter” rather than cold “stimuli”, ensuring the plants bloom in the right season.

VACANCY - Calling outstanding researchers! Apply TODAY for our Independent Research Fellowships Leading to Tenured Faculty Positions at the John Innes Centre Find out more: okt.to/KfP5oU

Most of the world's largest flowers (genus Rafflesia) are now on the brink of extinction Malabrigo et al. 📖 ow.ly/QnvZ50PPl67 Wiley Plant Science

Very excited to share this preprint from my postdoc work with Caroline Dean, where we investigated how polymerization domains in Arabidopsis VEL proteins contribute to epigenetic silencing mediated by PRC2! biorxiv.org/content/10.110…