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Online now: Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer dlvr.it/SbhR0m

New in Immunity: a team led by the Ming Li at MSK reports a unique function for tumor-associated macrophages (TAMs) in dampening tumor immunity — an immune regulation mechanism they're optimistic might be targeted with #immunotherapy in the future. cell.com/immunity/fullt…

Glad to share a holistic immuno-oncology perspective through the lens of #TGFb Nature Rev Immunol with implication for preclinical model choice for drug testing rdcu.be/cZJ5r

Glad to share a perspective on nutrient acquisition and metabolism control of macrophage responses in tumor Immunity with Cancer Research Institute fellows Xian Zhang Liangliang Ji authors.elsevier.com/a/1gOy23qNrUqG…

Check out this perspective on nutrient acquisition and metabolism control of macrophage responses in tumor, a collaboration between Xian Zhang Liangliang Ji & Ming Li Immunity #ASCO23 hubs.li/Q01RP-dM0

Celebrating cancer immunology and immunotherapy discoveries supported by #CancerResearch (70 years and going strong) and other agencies to create a world #Immune2Cancer

Our lab's latest paper on peripheral tolerance mechanisms in skin is out now in nature. Congrats to Martina Damo for leading this and thanks to collaborators from Krishnaswamy Lab and Yale Dermatology. nature.com/articles/s4158…

Reprogram tumor-associated macrophages to outmatch cancer cell competition. Excited to share our new study nature by brilliant Cancer Research Institute fellow Xian Zhang and collaborators! rdcu.be/dfA6f

Excited to introduce scKINETICS, an algorithm for joint inference of gene regulatory mechanism and cellular velocity, co-developed by the amazing duo of Cassandra Burdziak and Julia Zhao academic.oup.com/bioinformatics…

Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells.

Reprogram tumor-associated macrophages to outcompete endothelial progenitor cells and suppress tumor neoangiogenesis. Excited to share our new study Immunity by brilliant Mia Do , Wei Shi, and Cancer Research Institute fellow Liangliang Ji and collaborators!

Deeply missing Albert. He is such as an exemplary scholar.

Thanks to Memorial Sloan Kettering Cancer Center for covering it!

28 cancers are now treatable with immunotherapy, thanks to the work of the Cancer Research Institute. Explore our Impact Report, and discover how CRI is transforming the lives of cancer patients on a global scale: bit.ly/3u0MMLe #CancerResearch #Immunotherapy

Glad to share our review article Annual Reviews on tissue-resident innate and adaptive lymphocytes in cancer. Defining their identities and sensing mechanisms shall guide targeting such prewired and priming-dependent defense responses for cancer therapies. doi.org/10.1146/annure…

Now online! Dynamic allostery drives autocrine and paracrine TGF-β signaling dlvr.it/TDJlBm

Congrats to Andrea ⁦The SchietiLab⁩ for the very well deserved ⁦Cancer Research Institute⁩ Frederick W. Alt Award! Brilliant science for cancer cure!!

High rate ATP production accounts for the Warburg Effect, perhaps in support of energy-demanding processes such as PI3K signaling in effector T cells