Please share! Great opportunity for those keen on pursuing cardiovascular genetics🫀🧬. Fantastic mentor, colleagues, and research environment. Please come and join us!

🔥 Hiring a funded postdoctoral fellow position in human genetics! Come join us CGM at MGH Broad Institute Harvard Medical School!
🔥 Apply: partners.taleo.net/careersection/…

Fascinating discovery of a common variant (eQTL and pQTL) that points to intellectin-1 (encoded by ITLN1) as a therapeutic target to reduce mucus plugging in type 2 inflammation high (T2-high) asthma.

Everman et al. Nat Comm nature.com/articles/s4146…
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A non-coding upstream

From genetic associations to genes: methods, applications, and challenges: Trends in Genetics cell.com/trends/genetic…. A review paper from a team effort led by Ting Ting Qi

Online now: Genome-first evaluation with exome sequence and clinical data uncovers underdiagnosed genetic disorders in a large healthcare system dlvr.it/T6HKCs

Our SBayesRC method is now published in Nature Genetics! SBayesRC is a full Bayesian method for polygenic score prediction that can analyse all common variants jointly with functional annotations in a single step. Zhili Zheng Institute for Molecular Bioscience nature.com/articles/s4158…

Managing differential performance of polygenic risk scores across grou... sciencedirect.com/science/articl…

Great GWAS paper diving deep into the contributions of germline variants to kidney cancer in 29k cases and >800k controls. I particularly love the discovery of a VHL 3' UTR variant, seen in ~10% of African and ~0.01% of European ancestries, that increase the risk of clear cell

'Egyptian Genome Project aims to sequence genomic variants of 100,000 apparently healthy Egyptian adults, with around 8,000 individuals suspected to have a genetic disease, as well as 200 ancient Egyptian mummies.' 🔥
Elmonem et al. Nat Gen
nature.com/articles/s4158…

One subcutaneous injection of monoclonal antibody (L9LS) against malarial parasite protein provided 70% protection against malarial infection (77% against clinical malaria) over a period of six months. Amazing!
Kayentao et al. NEJM
nejm.org/doi/full/10.10…

Plan ahead when developing your NIH grant application as the process takes months, not weeks! 🗓

For more tips, join Extramural Research and @CSRPeerReview for a May 15 webinar as experts provide a walk-through of the process for beginners. Register today: go.nih.gov/NIHgrantswebin…

The use of artificial intelligence (AI) in health care has seen remarkable growth in the past 5 years.

A new Review from The Lancet Digital Health examines how AI could improve care management, clinical decision-making efficiency, and further research areas 👉 hubs.li/Q02v0wl50

Just published
Our review article of all the medical #AI randomized controlled trials The Lancet Digital Health
thelancet.com/journals/landi… Ryan Han Julián Nicolás Acosta Pranav Rajpurkar

Delighted to share our work demonstrating that PRS and clinical risk factors should be jointly considered towards personalized medicine. Honored and grateful to be guided by my great mentor Pradeep Natarajan and to work with an awesome team!

Genetic risk shouldn't be considered in isolation. Our work led by Buu Truong shows how clinical risk factors and a coronary artery disease polygenic risk score interact to optimally inform coronary artery disease risk. sciencedirect.com/science/articl… Med by Cell Press

Investigational medicines with human genetic support for their mechanisms are 2.6-fold more likely to successfully make it to regulatory approval vs those without nature.com/articles/s4158… nature

Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158…

I break the key findings down panel by panel in this thread: x.com/cureffi/status…

The GLP-1 drug family drug RCT evidence list now includes:
✓ Diabetes
✓ Obesity
✓ Obesity + heart disease
✓ Obesity + heart failure w/ preserved EF
✓ Obesity + sleep apnea
✓ Prevention of kidney damage w/ diabetes
Potential:
—MASH (liver disease)
—Parkinson's
—Alzheimer's

Genetic variation is relatively poorly studied in the Middle East, particularly where endogamy and consanguinity are more common. Among 6K WGS in Qatar, 2 in 3 (!) was a carrier for a pathogenic mutation for an autosomal recessive condition. link.springer.com/article/10.118…

Vaccination reduced the risk of #LongCovid by ~40% in the entire population (5.4 million) of Norway
thelancet.com/journals/lanre… and reduced cardiovascular and thrombotic events Nhung Trinh
The Lancet Respiratory Medicine