Three papers in Nature identify CRL4-AMBRA1 as a key regulator of D-type cyclin stability, regulating cell cycle progression in cancer and development nature.com/articles/s4158… nature.com/articles/s4158… nature.com/articles/s4158…

News & Views: Proteins called D-type cyclins are key components of the core cell-cycle engine, which drives cellular division. Three Nature papers provide the long-sought answer to how D-type cyclins are normally degraded. go.nature.com/3dk7VoW

“These results advance our understanding of replication-phase entry and genomic integrity...” Read more: nature.com/articles/s4158…

Proud to be co-last author together with Cecconi Labs Thank you to everybody!!!! TFG binds LC3C to regulate ULK1 localization and autophagosome formation | The EMBO Journal embopress.org/doi/full/10.15…

Thrilled to share our publication out today in Nature Communications. A big thanks to all our collaborators and Kræftens Bekæmpelse @LEOfondet @melanomaReAlli who greatly supported this study!!! nature.com/articles/s4146…

Excited and proud to share our new paper, published in Acta Neuropathologica. We have identified a combination therapy (autophagy +STAT3 inhibition) to potentially counteract high-risk medulloblastoma link.springer.com/article/10.100… Thanks to Cecconi Labs Fondazione AIRC per la ricerca sul cancro

Excited to share work from Dr. Fangfei Qu on SCLC brain metastasis, with @NeoPascaLab and Monte Winslow's Lab. In brief, Fangfei identified functional interactions between SCLC cells and astrocytes critically contributing to the growth of SCLC brain mets biorxiv.org/content/10.110… 1/6

Delighted to share a brief Punctum wrote with @Maemil3 on how the pro-autophagic protein AMBRA1 regulates cyclin D stability and cell cycle, with substantial implications in genome stability tandfonline.com/eprint/WXUAJQJ…

Post-doctoral position in Rome #autophagy #medulloblastoma #bambinogesu FrancescaNazioLab

Congratulations to Antonio Marzio, a postdoc in @thepaganolab, for his study published online today Cell 1/8 sciencedirect.com/science/articl…

We are happy to host students/postdocs from Ukraine / Україна 🇺🇦 for temporary placements in our labs to help carrying their education & research #biochemistry, #lifesciences IBC2 Goethe-Universität Get in touch biochem2.com #science The Kyiv Independent #Ukraine #ScienceForUkraine 🇺🇦

Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability… read the paper on #celldeathdifferentiation go.nature.com/37KZ2UM

📢Check out the #Review "Canonical and Noncanonical Roles of Fanconi Anemia Proteins: Implications in Cancer Predisposition" 👏by Giacomo Milletti, Luisa Strocchio, et al. Bambino Gesù Access the paper here➡️ mdpi.com/2072-6694/12/9… Fanconi anemia; DNA repair; mitochondria

Please RT thanks, paganolab.org

If you desire to get an insightful overview of cell-cycle-related kinases… READ US on cell death and differentiation, by Giacomo Milletti! eur03.safelinks.protection.outlook.com/?url=https%3A%… CDD press gerry melino Kræftens Bekæmpelse Fondazione AIRC per la ricerca sul cancro Danmarks Grundforskningsfond Novo Nordisk Foundation Ministero della Salute Università Cattolica Bambino Gesù

Check out our new Review in Cell Death and Differentiation CDD press ! "Cyclers’ kinases in cell division: from molecules to cancer therapy" We explore the highly orchestrated network of cell cycle-related kinases! Here's a link for free access rdcu.be/dh27P

Congrats Fiorella, you deserved! A new great piece from our lab!!!

Very happy to share my second paper from grad school out today Science Magazine! Read about how midnolin catches nuclear proteins for ubiquitination-independent proteasomal degradation. Stay tuned for more exciting work to follow. science.org/doi/10.1126/sc…

Our study on SCLC brain metastasis is out! rdcu.be/dnyzz Thanks again to all, including Zhe Wang Nature Cell Biology. A great effort by Fangfei and all the authors since the pre-print was first posted 2 years ago!

Excited to share (with my 8 followers) graduate student Ernst Schmid’s “SPOC” classifier, which can pick a good AlphaFold-Multimer prediction out of a crowd, and predictomes.org, a database of PPIs in the genome maintenance space. biorxiv.org/content/10.110…