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An impressive historical review by Gurdon & Hopwood (2000) on how Xenopus was introduced to experimental biology. I knew that Xenopus was used for pregnancy text, but did not know about the fascinating story of Lancelot Hogben, who made this happen. 1/11 ijdb.ehu.es/web/paper.php?…

This week’s #FluorescenceFriday user is Dominic Shayler! #HCRimaging enabled Dominic to validate his single-cell RNA sequencing data through reliable ISH results, even from poorly characterized genes. Check out his remarkable HCR™ RNA-FISH images of human retinal tissue here:

mapzebrain, the open-source atlas of the zebrafish brain, now also contains detailed gene expression maps. The atlas allows seamless integration of diverse data modalities, making it an important research tool accessible to everyone. science.org/doi/10.1126/sc… Inbal Shainer 🎗️ @Enmyco

Thank you Lisanne Schulze, David Zada and Matt Lovett-Barron for highlighting our work. Proud to see our paper and resource out and hope it will help advancing zebrafish research in the years to come. Go Fish! 🐟 science.org/doi/10.1126/sc…

This week’s #FluorescenceFriday user is Isabel Holguera! #HCRimaging of deadpan mRNA (blue) allowed Isabel to identify neural stem cells in the Drosophila optic lobe (outlined with a white dashed line) and central brain. Hoechst (orange) marks cellular doi.org/jxrz

This week’s #FluorescenceFriday users are Madeline Ryan and Tony Yu-Chen Tsai! Through #HCRimaging, Madeline and Tony were able to map out cell-type specific expression of various adhesion molecules in the zebrafish spinal cord. Check out their stunning images #withHCR here:

As we celebrate International Women's Day this year, let's recognize the invaluable contributions that #WomeninScience have made across all industries. Thank you to all the phenomenal women at MI who have each played a crucial role in making #HCRimaging a reality! #IWD2023

I may be in lab on a Saturday, but at least the staining is gorgeous! Possibly the prettiest imaging I’ve ever done. Prdm1a in magenta, myoD1 in green, on 10ss ZF embryos. I ❤️ HCR!

I am so happy to share the main portion of my PhD work AmphiSpace, out now in preprint! 🎉 We investigated the evolution of the anterior neuroectoderm to trace the origin of the #forebrain. What did we find? Have a look at this tweetorial to find out! 🧵 tinyurl.com/53pbph8t

The making of chelicerate appendages: Dual Functions of labial Resolve the Hox Logic of Chelicerate Head Segments UW-Madison iBio Molecular Biology and Evolution #Hox #evodevo #arachnids academic.oup.com/mbe/article/40…

This week’s #FluorescenceFriday user is on Petra Popovics, a former lab member in @labRicke at University of Wisconsin O'Brien Center! #HCRimaging helped Petra Popovics identify different immune cell types in the mouse prostate and localize Spp1 expression in luminal microphages. doi.org/j265

This week’s #FluorescenceFriday user is Eric Horstick! #HCRimaging enabled Eric Horstick to test for gene expression and neural activity changes in vivo. View his beautiful HCR RNA-FISH images of larval zebrafish below, and check out his lab horsticklab.org

This week’s Research Spotlight is on the Lopéz et al. (2023) publication, “Molecular characterization of nervous system organization in the hemichordate Saccoglossus kowalevskii!” #HCRimaging enabled Lopéz et al. to characterize the expression of multiple doi.org/j4mz

This week’s #FluorescenceFriday user is Joshua Raji, a postdoctoral fellow in the Potter Lab @flyknows! @jojshmanraji’s favorite aspect of #HCRimaging is that whenever he visualizes his images on the confocal microscope, “the signals are bright with less background, and it always

This week’s #FluorescenceFriday user is Julia Peloggia de Castro, a PhD candidate in Piotrowski Lab at Stowers Institute! @jupeloggia studies developmental plasticity using the zebrafish lateral line and ionocytes. #HCRimaging enabled her to map gene co-expression with single cell

Excited to share that our cuttlefish brain atlas is now out in Current Biology! Check out our website Cuttlebase.org and play around with the brain of this crazy camouflaging cephalopod. It was an amazing team effort 🐙✨ authors.elsevier.com/sd/article/S09…

This week’s #FluorescenceFriday user is Madeline Ryan, a research technician in the Tony Yu-Chen Tsai lab! Madeline Ryan uses #HCRimaging as a robust way to map cell-type expression patterns of different adhesion molecules and signaling pathway players in the developing zebrafish

As the year draws to a close, we'd like to express our gratitude to all participants in #HCRimaging's 2023 #FluorescentFriday Spotlight Series. We look forward to continuing to showcase our users and their research throughout 2024!

Go Naeem Nadaf!

This week’s #onlywithHCR Series features the Bedois et al. (2024) publication, “Sea lamprey enlightens the origin of the coupling of retinoic acid signaling to vertebrate hindbrain segmentation.” With #HCRimaging, Alice M. H. Bedois and her colleagues were able to investigate how