Have you ever wondered how to generate splicing factor isogenic cell lines to study of splicing dysregulation in a context-dependent manner? We have a solution. In the paper out today Cancer Research Communications , we describe a new method called PRECIS.

Recently published: Engineering oncogenic hotspot mutations on SF3B1 via CRISPR-directed PRECIS mutagenesis, by Mike Fernandez et al. bit.ly/4e6l01s Mike Fernandez Lili Wang Lab City of Hope UC Riverside CNAS #openaccess

Dynamic conformation: Marching toward circular RNA function and application. . In this perspective for our #RNA focus issue, Ling-Ling Chen and colleagues discuss the importance of circular RNA conformation in circRNA biology. dlvr.it/TF5cFq

Online Now: BRCA1 levels and DNA-damage response are controlled by the competitive binding of circHIPK3 or FMRP to the BRCA1 mRNA dlvr.it/TF9pMp

Excited to announce that I have been awarded the HGSAA award by ASH! Looking forward to meeting and discussing science with everyone at #ASH24 in a few months.

Congratualtions to Mike Fernandez on being awarded a Graduate Student Abstract Acievement Award for the 66th annual meeting of the American Society of Hematology. Great job Mike!!! IMGS is excited that your work is being recognized within your field. City of Hope Prof Ed: Ph.D. & Master Programs

Huge shoutout to the NCI Division of Cancer Biology for funding this work with the F31!

Online Now: ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR dlvr.it/TFkQlF

This month marks our 3-year anniversary! As we celebrate this important milestone, we thank our authors, reviewers, and editors for helping the journal uphold the highest standards of scientific rigor while broadening the accessibility of innovative cancer research. #openaccess

The first from my group is my graduate student, Mike Mike Fernandez, who is presenting on SF3B1 mutation in CLL and the loss of Y chromosome. Mike is also a recipient of the prestigious HIP GSAA award from ASH this year! shorturl.at/2wjek #ASH24 #CLL #SF3B1 #LOY

I am sailing in place where the sky is blue and where the environment is hopefully less toxic. bsky.app/profile/mikemf…