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Beautiful first day for our lab retreat, visiting Grasmere, Rydal Caves and even warm enough for a swim

Day 2 of our visit to the lakes we trekked to the summit of Silver How before heading down to Grasmere

Brilliant few days away with the whole team in the Lake District. Taking in the sights in glorious weather and enjoying spending lots of time together

Our latest paper just out in Nature Chem Biol describes highly unexpected cryptic enzymology, not seen before in Nature, and provides a new way to synthesise peptides (future therapeutics) using ligase enzymes. Nature Chemical Biology Manchester Institute of Biotechnology nature.com/articles/s4158…

We are having a great time at Directing Biosynthesis #DBVII. Some fantastic lectures including a super talk from Guangcai Xu on the cryptic enzymatic assembly of peptide anticancer agents. doi.org/10.1038/s41589…

Check out our new approach for enzymatic synthesis of peptide therapeutics just published in Nature Chem Biol. This Research Briefing includes a summary of the results, author insight Manchester Institute of Biotechnology, along with opinions from the reviewer and editor Nature Chemical Biology. doi.org/10.1038/s41589…

Sydney, Izzy, Guangcai, Puja, Waraporn and Elsa from our lab @MIBUoM had a great time at Directing Biosynthesis #DBVII. Many thanks to the organisers Royal Society of Chemistry. Looking forward to the next conference in this series DBVIII.

Peptides are important for medicine production, but they are currently made via unsustainable methods. Micklefield Lab have found a brand new enzyme that produces peptides more efficiently. This could be used to treat many diseases including cancer. manchester.ac.uk/discover/news/…

.Guangcai Xu et al explain how nature assembles molecular weapons possessing reactive functionality (warheads) to inhibit essential biochemical machinery and outcompete other organisms in the environment: doi.org/10.1038/s41589… go.nature.com/3LrIXUx

We are delighted to be working with Exactmer and Imperial who will be helping us with process development and scaling up our labs enzyme technology for the cleaner assembly of modified nucleic acid therapeutics. exactmer.com/exactmer-secur…

Here is Guangcai Xu presenting our lab's latest research at the GIM 2024 conference in Shanghai.

PhD positions in Chemical Biology starting Sept 2025 in our new labs at Imperial College, in the centre of West London’s expanding Innovation District. Imperial College London, Imperial Chemistry, National Implementation Research Network (NIRN), White City Innovation District. Deadline 18 Nov 2024. More details here: jobs.ac.uk/job/DKN054/phd…

Please join us in welcoming Micklefield Lab who today has joined the Department of Chemistry Imperial College London. We are super excited to have you become a member of our community @ MSRH White City Innovation District Imperial Sciences Royal Society of Chemistry #chemicalbiology ICB Centre of Doctoral Training Imperial Engineering Imperial Enterprise

Our latest paper in Angewandte Chemie introduces enzymatic cascades for more sustainable amide synthesis including C–H bond amidation and CO₂ fixation pathways to greener pharmaceuticals.🌱Imperial College London, Imperial Chemistry, Manchester Institute of Biotechnology onlinelibrary.wiley.com/doi/10.1002/an…

Enzymatic Cascades for Stereoselective and Regioselective Amide Bond Assembly (Jason Micklefield and co-workers) Micklefield Lab #OpenAccess • onlinelibrary.wiley.com/doi/10.1002/an…

Welcome to the Department Joe! Very much looking forward to you joining our community Josef Boronski

Our latest paper reports a new integrated catalytic fluorination method. We merge enzymes with photoredox catalysis for more sustainable and selective synthesis of fluorinated motifs found in many pharmaceuticals.💡Imperial College London, Imperial Chemistry, Manchester Institute of Biotechnology. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cc…

PhD positions in Chemical Biology starting Sept 2025 in our labs at Imperial College London, Imperial Chemistry. Deadline is 25 April 2024. More details here: jobs.ac.uk/job/DMQ976/phd…

Our lab hosted several successful Marie Curie Fellows in the last few years. Email us if you are interested in research at the chemistry-biology interface & want to apply for a MSCA Fellowship at Imperial College London. Imperial College London, Imperial Chemistry …sklodowska-curie-actions.ec.europa.eu/calls/msca-pos…