Our paper is online! We (as in Nader) assayed the human proteome for transcriptional activators with a pooled screen and found over 200 activators. These included both well-characterized activators and unknown proteins. sciencedirect.com/science/articl… 1/6

Drug combinations can overcome therapy resistance but the number of possible combinations is vast. Today we published @nature a study using pharmacological screens in cancer cell lines and multi-omics analysis to identify effective combinations in defined molecular backgrounds.

we are recruiting another postdoc! general area is computational approaches to understand and predict synthetic lethality in cancer. email me for informal queries. Full job description here: ucd.ie/workatucd/jobs/ (reference 014256). Closing date: March 25th. RTs appreciated

Postdocs available in RNA capping enzyme regulation in pluripotency and differentiation... researchgate.net/job/961302_Pos…

Interested in regulation of gene expression in cancer signalling? We are looking for a new postdoc. How do oncogenic signalling pathways influence the RNA capping enzymes? How does targeting the capping enzymes influence cell growth, proliferation? beatson.gla.ac.uk/Postdoctoral-F…

Happy to share! Paralog genes in cancer. Experimental validation of paralog pairs (RPP25/L, DNAJC15/19, DDX3X/Y and more): Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes cell.com/cell-reports/f…

Wondering how gene essentiality can change across genetic backgrounds and environmental conditions? Postdoc Nuria Bosch reviewed it here: sciencedirect.com/science/articl…

NIH-wide search for tenure-track investigators: Phantastic opportunity to start a fully funded lab NIH, incl. @NCIResearchCtr Molecular Targets Program (ccr.cancer.gov/molecular-targ…). Application deadline for Stadtman Investigators September 30, 2022. irp.nih.gov/careers/facult…

The Donnelly Centre for Cellular and Biomolecular Research at the Univ of Toronto is inviting applications for three tenure track assistant professors. These are broad searches in the area of functional genomics (2x) and computational biology 1/2 thedonnellycentre.utoronto.ca/current-opport…

Drug target identification is at the heart of drug development, and we’ve been working to change how it’s been done. We present DeepTarget: a new computational tool to characterize a drug’s mechanism of action in-depth beyond its primary target. 🧰🧵👇 biorxiv.org/content/10.110…

Donnelly Centre at Univ of Toronto is inviting applicants for three (3!) tenure-track positions at the level of Assistant Professor in the fields of computational biology & genomics. Learn more about the positions & how to apply 👇👇 bit.ly/DonnellyRecrui…

Happy to share our critical evaluation of reproducibility metrics for context-specific CRISPR screens with my former colleagues Henry Ward Michael Aregger UMN Computer Science & Engineering Donnelly Centre and my first paper at Rheinische Friedrich-Wilhelms-Universität Bonn Uniklinik Bonn authors.elsevier.com/a/1h5ag8YyDfmx…

Excited to share our work mapping the PARP inhibitor response network! We measured ~300,000 genetic interactions, describe the genome stability network, identify context-dependent GIs revealing unknown PARPi responses, and more—check here for details! biorxiv.org/content/10.110…

Excited to share our work on how environmental perturbation rewires functional connection between human genes. @ucsf Arc Institute doi.org/10.1101/2023.0…

Excited to share our recent work published in Med by Cell Press, the very first systematic review and analysis on synthetic lethality in oncology, led by Alejandro Schäffer, Youngmin Chung, Ashwin Kammula and Joo Sang Lee. Buckle up! 🚀 cell.com/med/fulltext/S…

Check out our CRISPR genome-scale exon perturbation study Molecular Cell. We identified exons influencing cell fitness and uncovered a novel mechanism by which #splicing affects #transcription. Michael Aregger Arun Prasath Damodaran Meisheng @NCIResearchCtr NIH doi.org/10.1016/j.molc…

A big thank you to the Molecular Cell editorial team for featuring our work in a meet-the-authors article. Arun Prasath Damodaran, Meisheng, and I share our scientific journeys and experiences. Check it out: sciencedirect.com/science/articl…

We are thrilled to share the THIRD study of our series which sheds light on the genetic interactions between transporters and links them to the metabolic network: doi.org/10.1101/2024.1…

Thanks to the NCI RNA biology community for organizing a great retreat and congrats to YoungKyu Jeon and the other poster award winners!