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Wow ! Super exciting work! Key for studies of stem cells niche architecture 🔬

An #OscillatoryShearStress-α5β1 integrin-ABL1-YAP cascade in #EndothelialCell promotes #VascularInflammation (likely not apoptosis/proliferation) & Apoe-/-🐭#Atherosclerosis Elevated p-ABL1 Tyr412 & p-YAP Tyr357 on athero-prone🐭aortic endothelium &👤athero-lesional endothelium

Calling mechanobiology PhD students and postdocs to share their work in our 2024 - 2025 Future Leaders in Mechanobiology Seminar Series! Zoom, 3rd Wednesday of the month, at 11am ET (8am PT, 10am CT), and all are welcome to attend. (Self-)nominate here: bit.ly/4cWdxBF

Published in Development. Checkout Go-Nuclear 3D nuclei segmentation pipeline using PlantSeg and StarDist.

A deep learning-based toolkit for 3D nuclei segmentation and quantitative analysis in cellular and tissue context Read this Techniques and Resources Article by Athul Vijayan, Tejasvinee Mody, Qin Yu, Kay Schneitz Kay Schneitz and colleagues: journals.biologists.com/dev/article/15…

Now Online What does it take to build a nucleus? dlvr.it/TB0yRm

From MBoC Tamal Das is excited to share latest findings on how matrix stiffness affects mitochondria! Study reveals perinuclear clustering on stiff matrix & its importance in priming stem cells towards osteogenesis. #microenvironment #mitochondria doi.org/10.1091/mbc.E2…

The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery. nature.com/articles/d4158…

This is rich - one of the primary reasons scientists don't have a lot of time to think is that @nature and its ilk have promoted a culture where the primary goal of science is to produce bloated Nature papers that require lots of time and money, but little thought, to produce.

Our new paper on 3D single-cell mapping of immune cells near pre-cancer lesions using CODA in a video. Watch until the end. More here: biorxiv.org/content/10.110…

My slides about Bio-Image Analysis with napari presented at BioImage Analysis and Data Processing Workshop 2024 in Prague organized by VMCF - Viničná Microscopy Core Facility are available here: zenodo.org/records/132688… Thank you Martin Schätz Zuzana Burdikova for the opportunity to teach with you again!🎓😃

7/ Optical microscopy is uniquely suited to observe dynamics in living systems and, with the advent of lattice light sheet microscopy (LLSM), we can visualize subcellular dynamics noninvasively at high resolution across all four dimensions of space and time.

Out today in Nature Materials, the updated version of our work on nuclear jamming in organogenesis 👁️🧠 Thanks to the reviewers (yes, thanks 😊), we have added a lot of new data. Check below for the new results... 🧵 ➡️rdcu.be/dQDm6

Cell biologists! This is a fantastic statistics primer custom made for you. Very practical, must-read! From Pollard lab five years ago: molbiolcell.org/doi/10.1091/mb…

It was a great pleasure to participate in the 30th Anniversary of the Adhesion and Inflammation Laboratory Adhesion and Inflammation Lab (LAI) / INSERM U1067 @univamu Inserm. Very interesting and inspiring lectures and the opportunity to meet wonderful and outstanding scientists.

Excited to share our latest work on an image analysis paradigm that combines cell state and morphology analyses of patient biopsies at single cell resolution to uncover clinically relevant head-and-neck #cancer phenotypes! Cell cell.com/cell/fulltext/… tweetorial👇

Very nice focus issue Current Biology on Physics and Biology. cell.com/current-biolog… Some of us wrote a perspective article on "Where physics and biology meet" led by Wallace Marshall and Deborah Taylor. cell.com/current-biolog…

AFM-based nanoscale characterization of physical interaction within hematopoietic stem cells niche at single-cell level biorxiv.org/cgi/content/sh… #biorxiv_cellbio

🚨 Excited to share our new preprint! tinyurl.com/yckfc9fb The bone marrow niche is crucial for HSC function. Decades of research have revealed its incredible complexity, with diverse cells, ECM, and molecules. But how can we measure the forces driving these interactions?🤔1/n

Expert's Dilemma: the more specialized you become, the less open you are to creative solutions from other fields. But the more you explore other fields, the more you risk losing credibility in your home field. Interdisciplinary work is still not really embraced by academia.