Nature research paper: Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements go.nature.com/3SDlIvT

A common SNP at TERT c.-245T>C further increases TERT transcription and might refine the prognostic power of BRAF+TERT promoter mutations in PTC 👇👇👇 Genetic trio of BRAF and TERT alterations and rs2853669TT in papillary thyroid cancer aggressiveness academic.oup.com/jnci/article-a…

New paper introducing RESHAPE, a method simulating genomes of hypothetical descendants that can be used as reference panels safeguarding against re-identification threats. Read more: nature.com/articles/s4358…. Great work done by Théo Cavinato!

Boutros Lab Peter Van Loo Kyle Ellrott Maxime Tarabichi UCLA University of Toronto The Francis Crick Institute Columbia Systems Biology Broad Institute Wellcome Sanger Institute Scientists accurately measure cancer evolution New study by global consortium provides insight into how tumors evolve to help develop more precise diagnosis and treatment strategies #NBTintheNews via UCLA Health uclahealth.org/news/release/s…

Application deadline for our EMBL-EBI Training sequencing course is 22nd July! It covers all qc and mapping steps, variant calling for short and structural variants, how to analyse both short and long read sequencing data, and the basics of how to build a pipeline. Spread the word!

Now online in Cancer Discovery: The History of Chromosomal Instability in Genome Doubled Tumors - by Toby Baker, Maxime Tarabichi, Peter Van Loo and colleagues doi.org/10.1158/2159-8… The Francis Crick Institute MD Anderson Cancer Center

🚀 Excited to share our latest research! We developed GRITIC, a novel method for timing genomic gains using bulk WGS data. Our findings reveal non-parsimonious evolution and increased chromosomal instability post-genome doubling in tumors. aacrjournals.org/cancerdiscover… #cancergenomics

I’m thrilled to shared that this August I’ll join the Department of Pathology of the University of Cambridge Cambridge University as a Group Leader. The Machado Lab will study the somatic evolution of the adaptive immune system to understand aging and disease.

PhD position available here in Bruxelles to work with us Maxime Tarabichi Marianne Rooman on #AI4Cancer, Leveraging AI to study #Cancer #Evolution. More details here euraxess.ec.europa.eu/jobs/254491

Does cancer #evolution & intra-tumour heterogeneity predict long-term relapse? We tested the evolutionary paradigm in prostate cancer clinical trials with long follow-up, combining genomics with digital histopathology: nature.com/articles/s4301…

Our new paper on 3D single-cell mapping of immune cells near pre-cancer lesions using CODA in a video. Watch until the end. More here: biorxiv.org/content/10.110…

We published today a study of Whole Genome Sequencing from over 2000 colorectal cancers from the Genomics England cohort. nature.com/articles/s4158…

Visionary scientist who’s been a driving force in cancer genomics and somatic evolution! Can’t wait to see what they’ll cook up at Quotient with all that brainpower!

The October issue of Cancer Discovery is online! The cover features features work by Toby Baker, Maxime Tarabichi, Peter Van Loo and colleagues on the history of chromosomal instability in genome-doubled tumors - read that and much more: aacrjournals.org/cancerdiscover…

From the October issue: The History of Chromosomal Instability in Genome Doubled Tumors - by Toby Baker, Maxime Tarabichi, Peter Van Loo and colleagues The Francis Crick Institute MD Anderson Cancer Center bit.ly/3zTPO7p

Very happy and excited to announce that I'll be starting my own research group at EMBL-EBI! The group will focus on lineage tracing, somatic evolution and the origins of cancer. Interested in doing a postdoc in the group or know someone who is? Please reach out!

ERC-funded 3-year postdoctoral position in bioinformatics looking at cancer epigenomics/epitranscriptomics available in the Jeschke lab at Bordet Institute: euraxess.ec.europa.eu/jobs/306461

Are residue conservation and solvent accessibility all you need for predicting the impact of mutations on proteins? Have a look to our manuscript biorxiv.org/content/10.110… Marianne Rooman Matsvei Tsishyn (IB)^2 Université libre de Bruxelles EPBruxelles

We are hiring a Senior Research Assistant to join my lab at Gustave Roussy. Please see job description below and, if interested, apply via the following link: emploi.gustaveroussy.fr/offre-de-emplo… drive.google.com/file/d/1L9ze63… PS. I'm no longer active here; updates at: bsky.app/profile/inigol…

🚨 Postdoc Opportunity 🚨 If you’re a molecular biologist interested in somatic evolution and cancer, my lab has an open postdoc position 🧬🔬 Apply here: euraxess.ec.europa.eu/jobs/315679 #Postdoc #CancerResearch #MolecularBiology #Genomics