Next Tuesday, we are super excited to have Matt McPartlon from Chai Discovery to share Chai-1, a foundation model for molecular structure prediction that performs at the state-of-the-art! Join us!

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…

Exciting new work from Qian Cong's group on predicting human protein interactome. Leveraging new eukaryotic genomes, new RoseTTAFold2 trained on +/- pairs of PPI and large distilled dataset of domain-domain interactions! 🤩 biorxiv.org/content/10.110…

Today we’re releasing Chai-1r, an updated version of Chai-1 with full support for restraints. Prompting Chai-1r with prior structural knowledge can boost accuracy by >2x. github.com/chaidiscovery/…

Chai-1 has always been available for commercial use via our server. Today, we're also making Chai-1(r) code and weights available under an Apache 2.0 license, which permits broad commercial use. github.com/chaidiscovery/…

We're excited to partner with the UK Government on OpenBind, an effort to create the largest open dataset of drug-protein interactions in history. More data → smarter AI models → better medicines gov.uk/government/new…

Chai Discovery (Joshua Meier Chai Discovery) just released Chai-2, a model for "zero-shot antibody design in a 24-well plate." The most existing result? Chai-2 successfully generated binders for 50% of the 52 targets they assayed (100x better than SOTA)! Some thoughts below:

Chai-2: Zero-shot antibody design in a 24-well plate １．Chai-2 is a multimodal generative model for protein design that achieves a 16% hit rate in fully de novo antibody generation—over 100x higher than previous methods—without requiring high-throughput screening. ２．In a

It's been a privilege work alongside the most uniquely talented group of individuals I've ever encountered on this breakthrough result Kevin Wu, Nathanael Rollins, Jacques Boitreaud, danny, Jack Dent , Joshua Meier, Zhuoran Qiao / 乔卓然 and others. You all made this possible!

Some scientists see the increasingly impressive results from protein binding models and argue "solving" this problem actually has marginal return on an end-to-end drug campaign in practice. Generally, they claim (1) traditional immunization / hybridoma assays are already quite

These guys are crushing all of the benchmarks 🦾. Congrats to Tomas Geffner, Kieran Didi and team!

Congrats to the winners! It's a privilege to work alongside Zhuoran Qiao / 乔卓然 every day :)

Excited to re-share work from Yo Akiyama and Zhidian Zhang on MSA pairformer.

🚀 Welcome to the portfolio, Chai Discovery! Their Chai-2 model achieved a 100x improvement in antibody design. This is how you transform drug discovery. Thrilled to back this world-class team: Joshua Meier Jack Dent Matt McPartlon Jacques Boitreaud For more on why we invested👉

Thanks to everyone on the Chai team for making this possible!

Thanks sarah guo for being with us from day one and even providing us our first office space 😊

Beyond excited to welcome Dr. Mikael Dolsten to the Chai Discovery board. His leadership in bringing transformative medicines to patients is unmatched, and we’re thrilled to have his guidance as we scale Chai-2 and beyond!

🚀 Chai Discovery has been named to the Endpoints News 11 list of the most promising biotech companies of 2025!