I’m a large nitrogen dewar. I provide essential pressure and inert gas to a top tier research lab. This is my daily routine.

SynNotch-driven IL-2 allows T cells to overcome immunosuppression in solid tumors. Amazing work by Kole Roybal, Matthew Spitzer, and Wendell Lim UC San Francisco Parker Institute for Cancer Immunotherapy to design circuits to provide the right cytokine to the right cell at the right time science.org/doi/10.1126/sc…

PhDONE!

Danny Thomas was born 111 years ago. I have always been amazed by his radical vision to open a hospital in Memphis, TN in 1962 that would treat all patients equally. stjude.org/directory/t/da…

We're heading into a tense night with the release of the video of #TyreeNichols fatal encounter with Memphis police. I covered similar deaths in Memphis for years. Here's a thread on why this case gained so much attention - and why it's _different_ from other cases. 1/18

“We've come up with a way to more efficiently and effectively bind and target cancer cells,” Peter Chockley says. Discover how his ‘molecular anchor’ improved chimeric antigen receptors against multiple cancer types in Nature Biotechnology. stjude.org/CAR-anchor-dom… #immunotherapy

Synapse tuning enhances CARs. Most impressive is tumor clearance with a single dose of CAR NK cells (No cytokines or other co-treatment) and functional persistance of NK cells to day 120 to reject tumor rechallenge. Great work Peter Chockley! nature.com/articles/s4158…

presenting the first Schwarz lab preprint🎉: A Novel Single Vector Intersectional AAV Strategy for Interrogating Cellular Diversity and Brain Function biorxiv.org/content/10.110… (1/n)

Interesting paper highlighting the role of CD47 in CAR T function. St. Jude Research

Impactful findings from @itsalexbeckett St. Jude Graduate School of Biomedical Sciences. This has implications for auto and allo CAR T therapy and also CD47 blockade and autoimmunity

Delighted to share our more recent work about IL-2-related, non canonical , synthetic CD8 T cell states, now published in ⁦Nature Immunology⁩ . Huge thanks to ⁦George Coukos⁩ , ⁦Santiago Carmona 🧬 🖥️⁩ , ⁦Melita Irving⁩ and the whole team. nature.com/articles/s4159…

A mind-blowing paper has come out today in nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/sc…). Today, a group of scientists from

Thesis defense completed ✅

Big news coming soon 🍾

If you want to learn more about our work on engineered cytokine receptors for CAR T cell therapy, check out the "Behind the Paper" on our recent Nature Biomedical Engineering article communities.springernature.com/posts/engineer…

Safety and anti-tumor activity of autologous Her2 CART in sarcoma. Congratulations Nabil, Meena and the extended team Center for Cell and Gene Therapy and beyond nature.com/articles/s4301…