Thank you to all the health care workers — who won’t have much of a Christmas this year. Bless you all. 🎄

Updated guidance from our CPG guideline panel COVIDScienceOntario - evidence and ethically based, multistakeholder, reflective of current supply challenges. LOTS of new stuff for mildly ill & outpatients: #fluvoxamine #budesonide #sotrovimab #remdesivir covid19-sciencetable.ca/sciencebrief/c…

CAR-T in 2L DLBCL - differences in study designs/populations likely explain different outcomes. Thanks to manalikamdar for help with the slide #lymsm #ASH21

Happy to share our study aggregating COVID19 vaccine response in heme cancer. Thank you Abi V Matthew Cheung Lisa Hicks and Stephen Betschel! Bottom line: lymphoid cancers, esp recent anti-CD20 Tx dramatically lower response onlinelibrary.wiley.com/doi/abs/10.100…

Really important data suggesting we should be COVID vaccinating patient prior to anti-CD20 based therapies.

Congrats to Inna Gong Abi V Lisa Hicks for this extensive summary of COVID vaccine seroresponses and relative benefit (compared to control) in persons with heme malignancies. #lymsm onlinelibrary.wiley.com/doi/full/10.10…

Always learn so much from Alison Moskowitz - editorial on precision approach to T cell lymphomas ascopubs.org/doi/full/10.12… #lymsm

As of today, It is illegal to intimidate doctors It is illegal to intimidate nurses It is illegal to intimidate patients, It is illegal to obstruct them from providing care or receiving it. This law was passed unanimously in the House of Commons, and it comes into force today.

News today of shortages of life-saving Covid drugs & HC approval of paxlovid (which will initially be in v short supply too). As a methodologist & a clinician, I wonder… how do you follow evidence-based guidance on drugs when you don’t have any drugs? 🧵 thestar.com/news/gta/2022/…

As we’re about to get access to Paxlovid….remember it’s co-administered with ritonavir for PI-boosting. With heme malignancy drugs, be aware of its CYP3A4 inhibition and use cautiously with venetoclax, ibrutinib, TKIs, anticoagulants, etc. #lymsm

New from COVIDScienceOntario - treatment of COVID-19 with updated guidance for mildly ill patients: NEW section on #paxlovid and REVISED section #remdesivir. covid19-sciencetable.ca/sciencebrief/c…

𝐉𝐮𝐬𝐭 𝐏𝐮𝐛𝐥𝐢𝐬𝐡𝐞𝐝: #Frailty in Patients With Newly Diagnosed Diffuse Large B-Cell #Lymphoma Receiving Curative-Intent Therapy: A Population-Based Study: buff.ly/39z7Z4Y Abi V @ancaprica @mattcheungmd Princess Margaret Cancer Centre #DLBCL #lymsm

Vitamin B12 deficiency is common and presents diversely. This article in CMAJ describes diagnostic criteria for vitamin B12 deficiency, common etiologies of vitamin B12 deficiency, and evidence-based strategies to treat vitamin B12 deficiency. cmaj.ca/content/194/24…

Vitamin B12 is necessary for normal bone marrow and central nervous system function. B12 deficiency can cause fatigue and pallor. Here are 5 things to know: cmaj.ca/lookup/doi/10.… Billy Silverstein Yulia Lin Matthew Cheung

Sinai Health/University Health Network Geriatrician, Dr. Shabbir Alibhai as well as Abi V @ancaprica @mattcheungmd et al. released a new study which explores #frailty in patients with newly diagnosed Diffuse Large B-Cell #Lymphoma receiving curative-intent therapy. To read: bit.ly/3NtG9Fh

Carence en vitamine B12 : Les patients peuvent parfois présenter des symptômes neuropsychiatriques; examiner l’alimentation et la médication est important — cmaj.ca/lookup/doi/10.… Billy Silverstein Yulia Lin Matthew Cheung

Vaccinated cancer pts had higher risk of breakthrough COVID-19 infection & poor outcomes incl. hospitalization & death, compared to controls without cancer, especially for those w/hematologic cancer or on active chemo. Third vaccine dose reduced this risk. ja.ma/3GqObhN

Congratulations team on this important contribution to our understanding of COVID in pts with cancer. Led by rising star Inna Gong . Bottom line: COVID outcomes worse in hem cancer and any on chemo. Booster shots help. Matthew Cheung Abi V Dr K., MD, MS, FASCO 🌎🇺🇸🇪🇺🇺🇦🌏

Congrats Clarissa Skorupski ⭐️ on this excellent 5 things to about about Preop anemia in CMAJ! Such a great team to work with Matthew Cheung! 🙌 @LMP_UofT Department of Medicine University of Toronto Sunnybrook Health Sciences Centre cmaj.ca/content/195/15…