Exciting news 🚀 Mathias Girbig and Georg Hochberg helped showing that essential proteins for animal #stemcell regulation are much older than previously thought, dating back over 700 million years. Check it out👓 mpi-marburg.mpg.de/1450571/2024-1…

Very cool and relevant work and another example of the modular evolution of transcriptional networks at the onset of animals. Here, Sox and POU are shown to be present in choanoflagellates, filastereans and, potentially, corallochytreans. So, yes, the unicellular ancestor

🚨Paper alarm Our new work on APC/C regulation revealed by high resolution cryo-EM structures together with the groups of Leifu Chang and David Barford has been published Nature Communications. Congratulations to Anna Höfler, Jun Yu and all other authors. 🔗nature.com/articles/s4146…

New paper from us and SYBORG by Luca Schulz : embopress.org/doi/full/10.10…. It's about the evolution of essentiality. This question has fascinated me for a long time: How does a component that was previously unnecessary for some function become essential for it?

Happy to see our work on Sox/POU origins covered in detail at the The Washington Post by Kasha Patel. Thanks to BEAP Lab (Biology & Ecology of Abundant Protists) and Sandie Degnan for their contributions: washingtonpost.com/climate-enviro…

New paper from the lab: rdcu.be/d2g28. You may remember the strange fractal assemblies we discovered in citrate synthase. Well, the reason we even found that protein is that we were interested in how conserved self-assembly is in an enzyme with a very basic function.

Happy to share our story on evolution of protein quaternary structure! We discover an astounding variation in assembly across evolutionary timescales contrasted by strong functional conservation suggesting a significant role of non-adaptive processes nature.com/articles/s4146… 👇🧵

First paper of our lab today nature by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! EMBL doi.org/10.1038/s41586…

Our TFIIIC story continues with our latest work in NAR (academic.oup.com/nar/advance-ar…). Using cryo-EM and single-molecule fluorescence microscopy (smFM), we explored questions that remained unanswered in our human TFIIIC structure. Wanna see the updated TFIIIC structure? 🧵🪡

Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC! Cool collaboration with the Müller and EustermannLab EMBL Details by the Wolfi below👇