Online now!✨RESEARCH: Song et al identify an NAD+-dependent metabolic checkpoint regulating HSC activation in young mice, that becomes dysregulated and drives HSC decline in aging nature.com/articles/s4358… rdcu.be/dOMAS

Interested in how to improve #reproducibility in your assays using human PBMCs? This study assessed the effects of different cell preparations on flow cytometry assays and uncovers differences in cell fitness. ➡️ ow.ly/Fr8u50TGVPs #ReadIH #immunology

💫NEW: Demetriades Lab Stephanie A. Fernandes Danae Angelidaki & co dissect the spatial separation of #mTORC1 activation and signaling. Differentially localized mTORC1 complexes phosphorylate distinct substrates in response to different amino acid supplies. nature.com/articles/s4155…

🗨️ WANNA TALK TO YOUR CELLS? Try out CellWhisperer – our new multimodal AI that turns single-cell RNA-seq analysis into a conversation. No coding needed, just chat in plain English. Short walkthrough below. Web app & bioRxiv preprint linked in the thread. Let's dive in! (1/9)

Zengqi Zhao, Qinghui Ai et al. delineate a novel mode of saturated fatty acid–induced mTORC1 activation and insulin resistance, which involves acetyl-CoA derived from fatty acid β oxidation and Tip60-mediated Rheb acetylation. hubs.ly/Q02TYf340 #diabetes

Qin et al. show that TCR signaling induces STAT3 phosphorylation through Lck/Fyn, and synergistically w/ cytokine signal, induces optimal STAT3 phosphorylation to drive TH17 cell differentiation hubs.la/Q02TfwGS0 📘 In our #Autoimmunity collection: hubs.la/Q02TfwHV0

Daiyong Deng, Pingping Hou et al. Rutgers New Jersey Medical School show that NFAT5 acts as a critical co-factor for SMAD3 and SMAD4 in driving TGFβ-induced epithelial-to-mesenchymal transition and resistance to KRAS-targeted therapy in #PancreaticCancer. hubs.la/Q02V6XF90 #SolidTumors

REVIEW Nature Rev Immunol Faezzah Baharom Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumor microenvironment nature.com/articles/s4157…

Great Friday Berkeley, holding our 13th mini-symposium of our T cell P01 program, NIAID Funding . Excellent discussions on details of the T cell signaling machinery, its relation to #autoimmunity and how we may leverage insights to improve #immune-therapies in #cancer settings

How do cells response to withdrawal of amino acids? It depends on the amino acid. ◼️Lysine withdrawal causes immediate cell-cycle stalling while the withdrawal of other amino acids allow for completion of additional cell cycles.

ONLINE NOW, New research from Stefano Comazzetto & Sean Morrison out in Blood Journal: Ascorbate (vitamin C) deficiency increases quiescence and self-renewal in hematopoietic #stemcells and multipotent progenitors. Read it ⬇️ ashpublications.org/blood/article/… #relentlessdiscovery

Differentiation fate of a stem-like CD4 T cell controls immunity to cancer nature.com/articles/s4158…

Transgelin 2 guards T cell lipid metabolism and antitumour function | Nature nature.com/articles/s4158…

CENCAT; an immunometabolic profiling tool that blends the SCENITH. Single Cell Metabolism approach with BONCAT click chemistry to measure metabolic dependencies of cell subsets Cell Reports Methods paper online now ➡️ cell.com/cell-reports-m…

In this Review, Douglas Hanahan, Olivier Michielin & Mikael Pittet (Ludwig Cancer EPFL) discuss how nearly all cell types in the #TME can be programmed to mediate - as functionally distinct subtypes - immunosuppressive programs. 🤓📖👇 bit.ly/3NGklbN

Just saw this one from a few months ago: nature.com/articles/s4158… Cool use of LIPSTIC, never crossed my mind to use it for something like this!

Spatial analysis identified Tregs as a source of local T cell repression, mediating resistance to KRAS-G12C-i and anti–PD-1 Febe van Maldegem Science Advances science.org/doi/10.1126/sc…

New in Journal of Clinical Investigation from Penn Medicine - Abramson Cancer Center Natural TCRs targeting KRASG12V display fine specificity and sensitivity to human solid tumors jci.org/articles/view/… Isolation of HLA restricted, mutant KRASG12V antigen directed T cell receptors (TCRs) from healthy donors and from