A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b doi.org/10.7554/eLife.…

The Get1/2 insertase forms a channel to mediate the insertion of tail-... sciencedirect.com/science/articl…

This week's fanart is by Sha Sun, Xia Li, and Malaiyalam Mariappan ° #biology #research #cell #compbio #ER #structural #protein #folding #communication #sciart

Honored & excited to be selected for Best of Biophysical Journal symposium Biophysical Society #BPS2023 Shout out to Mals Mariappan & @MoitrayeeLab for their pivotal contributions Yale Cell Biology biophysics.org/2023meeting/pr…

Yale Cell Biology Seminar Series: "Molecular Origami: The Delicate Art of Protein Folding and Misfolding and Its Relevance to Health and Disease" m.yale.edu/bmps via @yalemed

Multiple job opportunites in the Yale West Campus Cores - mass spec & flow cytometry. Join an established team of staff scientists in support of research across campus. Please RT buff.ly/3lbi9i8 #research #hiring #yale @YWCimagingcore

.yael udi et al. Rout Lab Rockefeller University present a new method for quantitative subcellular fractionation of a wide range of mammalian cells while maintaining nuclear integrity. bit.ly/404Jvpr Inna Ricardo-Lax #Biochemistry #Trafficking #Organelles

New work from Ron Kopito and Francesco Scavone reveal that UFMylation of ER translocon-bound 60S ribosome subunits promotes proteasome-mediated degradation of arrest polypeptides following ribosome stalling. 👏 biorxiv.org/content/10.110…

Check out the preview of our latest story at news.stanford.edu/2023/04/20/stu…

A beautiful story from Chao Sun and Erin schuman on how 19S proteasome caps can independently regulate aspects of synaptic biology. lovely to see it out!! science.org/doi/10.1126/sc…

🎉We are thrilled to share our exciting new collaboration with Inada Lab and Jingdong Cheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM

🚨Out now!🚨 Check out how cells adjust their tubulin mRNA levels in response to excess free tubulin. A 40-year-old puzzle solved! Wonderful collaboration with Eva Absmeier, Lori Passmore & Ivana Gasic 🧵 1/ cell.com/molecular-cell…

Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control: Cell cell.com/cell/fulltext/…

We usually think of mRNAs carrying the information needed to make a protein (the central dogma...). But how can the encoded protein control the fate of its encoding mRNA? 🤔 Check out our review on the topic 👇 cell.com/molecular-cell…

Nice reconstitution from Mals Mariappan. Nascent proteins from stalled ribosomes are polyubiquitinated and then promptly deubiquitinated, giving a second chance to fold. If a protein still can't fold, it exposes a degron, is re-ubiquitinated and degraded. biorxiv.org/content/10.110…

Checkout the recent work from our lab that demonstrates how glucose attached to a protein can direct the protein folding and molecular choreography of nascent chains in the endoplasmic reticulum.