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Fluorescent biosensors reveal the dynamics of life, but *quantitative* biosensing only works in transparent single cells... until now! andrewgyork.github.io/relaxation_sen… Maria del Mar Ingaramo figured out how to take robust quantitative measurements with fluorescent biosensors, in whole animals.

This. is. incredible! Maria del Mar Ingaramo is a magician. Check out the story of how she invented a spontaneously relaxing biosensor that allows for quantitative organelle/tissue specific measurements in whole animals & leverages its properties to circumvent autofluorescence 🤯

Beautiful story. I always fill with emotion hearing personal stories about the titans of the field. It brings another dimension to the science that we spend so much time with.

Interested in understanding and making new fluorescent biosensors? Come be part of this collaboration between the Tim Craggs lab @Craggs_lab and the Calico microscopy team! @andrewgyork Julia Lazzari-Dean

If you are interested in lysosomal biology, check out this super-sturdy pH sensor from Julia Lazzari-Dean. Do reach out if you want to try it out; we'd be stoked to help you give it a whirl!

Love this type of work that goes back to the fundamentals! It reminds you that we forgot that we did not know it all.

So useful and what a fantastic delivery! 'Monsieur Poisson is as dim as he should be'!?! And I am very glad that the Babylonians got their well-deserved credit.

A month ago, there wasn’t a general tool to measure protein interactions in live cells. It certainly wasn’t for lack of trying. If you’re thinking “but FRET! colocalization! FCS!”, read on! Andrea Volpato Ilaria Testa et al changed this nature.com/articles/s4158… Here’s my take:

I'm really proud of this work. Truly looking forward to see how much better we can make it, and what technology it unlocks.

Our scientists are using advanced technologies like #microscopy to visualize never-before seen aspects of biology. Learn more about why Kayley and her colleagues find Life at Calico so rewarding: bit.ly/3ScFDBn

A thought-provoking, page-turner exploration of a really cool technique that we are working on, brought to you by my favorite scientist/science writer of all times Julia Lazzari-Dean

Today, we are announcing Future House, a philanthropically-funded moonshot focused on building an AI Scientist. At Future House, our 10-year mission is to build semi-autonomous AIs for scientific research, to accelerate the pace of discovery and to provide world-wide access to

More about the miRFP photo-conversion in the NIR to red spectral region!

This is a cool system for evolving optogenetic tools, and it makes a surprising red LOV protein to prove it!

Hey magnetogeneticists! I'll be presenting our new results on a highly magnetic-field-sensitive AsLOV2 variant at the Big Quantum Bio meeting tomorrow Thursday, April 18, at 7 am PST/10 am EST/3 pm UK time @ groups.google.com/g/bigquantumbi…. See you there!

Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields. This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate. Can you tell where the magnet is? Want some? It's on Addgene now! addgene.org/219957/

MagLOV results reproduced✅ We cranked the LED power and found the response can be much faster! Absolute change roughly the same at each LED power, i.e. contrast change likely due to the background, not MagLOV response. Many thanks to the Calico folks for sharing their discovery!

Here's why our beautiful 🐸 paper is not about 🐸s and not about embryogenesis---a 🧵 biorxiv.org/content/10.110…