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Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein disq.us/t/4g8veed Arthur Neuberger @kirillnadezhdi2 Maria Karela

Happy to share structure of human TRPV4 in complex with the GTPase RhoA. TRPV4-RhoA contact interface reveals residues that are mutated in neuropathies, providing insight into disease pathogenesis. Great collaboration with the lab of David Zhang (MCW). disq.us/t/4h6p0om

The structure of human TRPV4-RhoA GTPase complex bound to agonist 4α-PDD reveals the mechanism of channel opening. Great collaboration with the lab of David Zhang (MCW). @kirillnadezhdi2 Arthur Neuberger Ira Talyzina

The structure of human TRPV4-RhoA GTPase complex bound to the antagonist HC-067047 reveals the mechanism of channel inhibition. Great collaboration with the lab of David Zhang (MCW). @kirillnadezhdi2 Ira Talyzina Arthur Neuberger disq.us/t/4h6p0om

Happy to share structure of human oncochannel TRPV6 in complex with cannabinoid inhibitor tetrahydrocannabivarin (THCV) from Cannabis sativa. THCV binds in portals to the channel pore central cavity. Arthur Neuberger Kirill Nadezhdin Maria Karela disq.us/t/4i18nm0

Would you like to learn about interplay between inhibitory g5 and potentiating cornichon-2 (CNIH2) auxiliary subunits determining properties of AMPAR synaptic complexes? Happy to share our new paper in NSMB. Shanti Pal Gangwar Laura Yen Maria Karela doi.org/10.1038/s41594…

First time polyamine is visualized in ionotropic glutamate receptor (iGluR) pore. Structures of AMPA receptor complexes with auxiliary subunits y5 and CNIH2. Collaboration with Aryeh Korman and Drew Jones (NYU). Shanti Pal Gangwar Laura Yen Maria Karela doi.org/10.1038/s41594…

Would you like to learn about interplay between inhibitory y5 and potentiating Cornichon-2 (CNIH2) auxiliary subunits determining properties of AMPA receptor synaptic complexes? Happy to share our new paper in NSMB. Shanti Pal Gangwar Laura Yen Maria Karela nature.com/articles/s4159…

First time polyamine is visualized in ionotropic glutamate receptor (iGluR) pore. Structures of AMPA receptor complexes with auxiliary subunits y5 and CNIH2. Collaboration with Aryeh Korman and Drew Jones (NYU). Shanti Pal Gangwar Laura Yen Maria Karela nature.com/articles/s4159…

Binding of antiepileptic drug Perampanel to complexes of AMPA receptor with auxiliary subunits y5 and CNIH2. Collaboration with Aryeh Korman and Drew Jones (NYU). Shanti Pal Gangwar Laura Yen Maria Karela nature.com/articles/s4159…

nature.com/articles/s4159…

Pentameric TRPV3: an artifact or a clue to channel function? Many structures of tetrameric TRP channel assemblies have been published. We discuss recent discovery of pentameric assembly of vanilloid TRP channel TRPV3 (doi: 10.1038/s41586-023-06470-1). sciencedirect.com/science/articl…

Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors frontiersin.org/articles/10.33…

Check out our new review: Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors. Maria Karela frontiersin.org/articles/10.33…

Special issue call for papers: Developmental Biophysics. ow.ly/cmBz50QrMRb

Enjoyed the excellent talk by Ed Twomey in the New and Notable section #BPS2024

RIP Jim Howe! Jim was a strong supporter of early career scientists and women in science! He would be sad to see the lack of representation in this otherwise brilliant slate!

Congratulations Art! We are so proud of you and so lucky to have you Biochemistry & Molecular Biophysics

Kainate receptor channel opening and gating mechanism | Nature doi.org/10.1038/s41586…

In today’s issue of Nature! Plant lectin Concanavalin A helped to open the channel of kainate receptor for the first time! The image is a cover candidate that was not selected by the journal. Shanti Pal Gangwar Maria Karela Kirill Nadezhdin Laura Yen Maria Kurnikova disq.us/t/4oqzkgx