What a fantastic #GTSRC24 meeting! With old and new friends Miyeko Mana and Marcus Goncalves

Impressive single agent activity for STX-478. ORR 21%. 23% (5/22) in HR+/HER2- BC; and 44% (4/9) in gyn cancers. 52% of patients had preDM/DM2 and only low grade hyperglycemia (23%).

"We show that a distinct subset of neutrophil-like monocytes, which we term cachexia-inducible monocytes (CiMs), emerges in the advanced cancer milieu and promotes skeletal muscle loss." nature.com/articles/s4146…

Retrospective body comp analysis in individuals taking semaglutide using automated CT. Chipping away towards potential biomarkers for responders vs non responders ajronline.org/doi/epdf/10.22…

Team #CANCAN members Giulia Biffi and Tobias Janowitz presenting research #cachexia #AACRPan24

👉Fenofibrate to prevent amputation and reduce vascular complications in patients with diabetes: FENO-PREVENT 👆The large-scale real-world evidence in the present study indicated that fenofibrate treatment in individuals with T2D was associated with a reduced risk of major

1/12 Thrilled that our story on HSD3B1 in ENZAMET is out Journal of Clinical Investigation ASCI! This is a new level of evidence for an inherited physiologic driver of prostate cancer mortality & potential treatment strategies! PCF Science ASCO AACR ACS Research jci.org/articles/view/…

ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits

Randomized Ph2, pts with treatment-naive metastatic PDAC were randomized to triplet chemotherapy with a medically supervised ketogenic diet. Primary outcome PFS but no PFS reported yet. aacrjournals.org/cancerres/arti…

The 2024 Lasker Foundation DeBakey Clinical Medical Research Award recognizes Joel Habener, Lotte Bjerre Knudsen and Svetlana Mojsov for the discovery and development of GLP-1 drugs that revolutionized the treatment of #obesity nejm.org/doi/full/10.10…

Lustgarten Foundation-AACR Career Development Award for Pancreatic Cancer Research - $300k or 3y for URM assistant professors. aacr.org/grants/lustgar…

congrats Baur Lab ! nature.com/articles/s4416…

*New Paper* doi.org/10.1016/j.ajcn…. Total energy expenditure measured using doubly labeled water in adults with major chronic diseases. There is still a critical gap in understanding energy needs for people with chronic diseases. Current nutrition guidelines do not fully account

Biggest medical discoveries of the week (🧵) 1/10 A new genetic condition, and insights into the gene that causes it: G protein, GNAI2 Patients' immune cells have impaired migration (videos) and hyperactivation - causing infections and autoimmunity science.org/doi/10.1126/sc…

Cheers to new friends! ⁦Helmholtz Munich | @HelmholtzMunich⁩ ⁦⁦Helmholtz Diabetes Center (HDC)⁩ #helmholtzdiabetes2024