Time for a celebration! We are very happy and proud that Oncode Institute will continue for another 5 years! oncode.nl/news/follow-up… Image by Jonne Raaijmakers, Rene Medema Lab, The Netherlands Cancer Institute

Great initiative by Utrecht University. For trips < 700km or < 8 hours, travel by train is the norm OR digital alternative if trip is non-essential. This new policy comes with a handy tool to check travel times and CO2 emission: uu-rightontrack.nl/en

Proud of this work we did in collab with Enrico Mastrobattista - With help of many of the lab, and a starring role of Pkerkhof who even came back from retirement to help finish experiments! 🤩🥰

Workshop on Wnt signaling as a drug target in human disease. March 17th, 2023 in Heidelberg (and virtual). For online participation, please register here: us06web.zoom.us/webinar/regist… Program: sfb1324.de/event/wnt-work… #Wnt SFB1324 DKFZ Uni Heidelberg EMBL DFG public | @[email protected] Please RT

Are you passionate about immunology and interested in collaborations with fundamental, translational and clinical immunologists? We offer the perfect environment to establish your research group! Center for Translational Immunology Infection & Immunity UMC Utrecht UMC Utrecht werkenbijumcutrecht.nl/vacatures/wete…

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Excited to share our new preprint from Madelon Maurice lab! 🎉 Susanna and I put in the effort to bring this story to life, now online as a preprint. Our work highlights how organoids can bring insights into Lkb1 & its link to cancer predisposition. biorxiv.org/content/10.110…

Looking forward! 👇

It was nice catching up with old and new colleagues/friends and all the new advancements in the Wnt signalling field. Exciting times ahead! A big thank you to the (vice) chairs for organising this GRC #Wnt2023 meeting 👏👏 Stephane Angers Mariann Bienz Madelon Maurice Ken Cadigan

Job Alert📢📢 We are recruiting postdocs in Protein Biochemistry bit.ly/45vrx1A & Cell Biology bit.ly/45ijcOX to join our lab Department of Biochemistry at Oxford University. Join us to tackle the next big challenges in the Wnt signalling field in a fun, collaborative & supportive environment!

Van der Krift et al. report on the mechanistic characterization of a novel, lipophilic antifolate that suppresses the growth of FPGS-deficient cells that are linked to methotrexate resistance and relapse in cancer patients Madelon Maurice UMCU_CMM bit.ly/3quDHsL

New group leader position Cell Engineering Faculty of Science, Utrecht University Utrecht University Check out vacancy link for more details👇👇👇Apply now! uu.nl/en/organisatio…

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Unlocking the 'FZD Code': In a molecular showdown, RNF43 and ZNRF3 reveal their unique preferences for depleting Frizzled receptors! Madelon Maurice's lab preprint from Jeroen Bugter discovers RNF43 & ZNRF3 aren't the molecular twins we thought they were. biorxiv.org/content/10.110…

Very pleased to announce the 2024 EMBO FEBS Lecture Course on signal transduction and cancer! 📍 Spetses (GRC) 🗓 August 18-26, 2024 Expect great speakers, motivating discussions and ☀️ Registration is open. Feel free to forward to whoever you think might be interested!

Had a blast at the TPD Keystone meeting! With a starring role of Jessie Kroonen presenting how we use our #SureTACs technology to degrade PD-L1 🤩 UMCU_CMM Laigo Bio #KSProteindeg24 #KSProximityTx24

Registration for the #EMBO #FEBS Spetses 2024 Lecture course on Signal Transduction in Cancer is open! PhD students and postdocs check out the exciting program with lots of science, fun and ☀️, application deadline April 1 👇 meetings.embo.org/event/24-signa…

Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signaling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations Madelon Maurice Jeroen Bugter UMCU_CMM bit.ly/3WcTol5

Our paper exploring the different mechanism and selectivity of Frizzled regulation by the presumed paralog tumor suppressor genes RNF43 and ZNRF3 has been published! No time to read? I tried to summarize the main message in a one minute video 👇

Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signaling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations Madelon Maurice Jeroen Bugter UMCU_CMM hubs.la/Q02FyGnP0