Excited to share our new study about how TREM2 splice isoforms can contribute to a pool of heterogenous sTREM2 and affect synaptic plasticity. Shweta Puntambekar Andy Tsai Israel Coronel Lasagna-Reeves Lab @BradyAtwood Pablo Martínez C. Kwangsik T. Nho @btlamb genomemedicine.biomedcentral.com/articles/10.11…

All the good stuff about the role of microglial Abi3 in AD in one simple read! Congratulations Hande Karahan, Jungsu Kim and the whole team!! The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies frontiersin.org/articles/10.33…

Amazing new data about microglial INPP5D and its role in Alzheimer’s Disease from my favorite people!

TREM2‐induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology onlinelibrary.wiley.com/doi/10.1111/bp…

Our latest paper dropped in Acta Neuropathologica. I appreciate (as always) my amazing mentor @timothyjhohman and co-authors. link.springer.com/article/10.100… A short "tweetorial" below: (1/9)

Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease jneuroinflammation.biomedcentral.com/articles/10.11…

🚨 New paper alert: Great to see it out today. It has been pleasure to be part of this study and this cool team. Congratulations to everyone 🎊

Liana Apostolova, MD, joined The Debrief on Scripps News to talk about the FDA's recent approval of Leqembi, a new drug to slow the effects of Alzheimer's disease. youtube.com/watch?v=FipURQ…

Results from TRAILBLAZER-ALZ 2, a phase 3 clinical study of an amyloid-targeting therapy (ATT) in development for people with early symptomatic Alzheimer's disease, were published in JAMA Network Click here to see the publication: e.lilly/42GdXqa

It's exhausting to keep up with ❤-ing all the tweets from #AAIC2023 that mention .MODEL-AD, .Adrian Oblak, .Lasagna-Reeves Lab, .@btlamb, .Liana Apostolova, MD, MSc, FAAN or generally anything related to .@NeurosciStark! Congratations y'all!! #proudstarkie #goteamstark

A recent article by Science Magazine highlights donanemab's effectiveness in slowing cognitive decline and associated risks. This milestone in advanced clinical trials for amyloid-targeting drugs offers hope for improved Alzheimer's treatments. science.org/content/articl…

Congratulations Dom Acri, PhD !! The first one is always special! :)

Happy to share the latest publication from the Meyer Lab, led by former PhD student Sailee S Lavekar, PhD. 1/6 nature.com/articles/s4159…

Congratulations ISRO !!!! #ProudIndian

Lee et al. show in mice that microglia activated by Aβ drive neuroinflammation, which subsequently induces tau and α-synuclein aggregation and the associated neurodegenerative phenotypes. tinyurl.com/yytz39zs

Generation of an inducible destabilized-domain Cre mouse line to target disease associated microglia biorxiv.org/content/10.110…

Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection nature.com/articles/s4358…

Check out our newly published work of skin tau biomarker for AD and rare tauopathies in Molecular Neurodegeneration! doi.org/10.1186/s13024…

"Although it seems clear that targeting amyloid β therapeutically makes sense, the question, who, when, & how to treat remains." A Therapeutics Review discusses the opportunities & challenges of passive anti-amyloid β immunotherapy in Alzheimer's disease: hubs.li/Q02ZSC0p0

Good to see 👍